{"id":"cefditoren-pivoxil","rwe":[{"pmid":"40901750","year":"2025","title":"Eudragit-based electrospun nanofibers for improving the solubility and permeability of cefditoren pivoxil: in-vitro, ex-vivo and histological assessment.","finding":"","journal":"Pharmaceutical development and technology","studyType":"Clinical Study"},{"pmid":"40794466","year":"2025","title":"Pharmacokinetic Study of Cefditoren Pivoxil in Breast Milk and Blood of Lactating Women.","finding":"","journal":"Biopharmaceutics & drug disposition","studyType":"Clinical Study"},{"pmid":"40530225","year":"2025","title":"Latent Non-typhoidal Salmonella in Macrophages as a Potential Cause of Persistent Appendicitis.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"40177453","year":"2025","title":"Localized Leg Erythema as the Primary Symptom of Scarlet Fever: An Atypical Presentation.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"39617399","year":"2025","title":"A case series study on the safety of cefditoren pivoxil use during the first trimester of pregnancy in Japan.","finding":"","journal":"Congenital anomalies","studyType":"Clinical Study"}],"tags":[{"label":"Cephalosporin Antibacterial","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DD16","category":"atc"},{"label":"Oral","category":"route"},{"label":"Tablet","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Acute exacerbation of chronic bronchitis","category":"indication"},{"label":"Bacterial pneumonia","category":"indication"},{"label":"Haemophilus Influenzae Chronic Bronchitis","category":"indication"},{"label":"Haemophilus Parainfluenzae Chronic Bronchitis","category":"indication"},{"label":"Haemophilus Parainfluenzae Pneumonia","category":"indication"},{"label":"Haemophilus influenzae pneumonia","category":"indication"},{"label":"Vansen Pharma","category":"company"},{"label":"Approved 2000s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[{"effect":"Hematuria","drugRate":"3.1%","severity":"common","organSystem":""},{"effect":"Diarrhea","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Increased urine white blood cells","drugRate":"2.3%","severity":"common","organSystem":""},{"effect":"Decreased hematocrit","drugRate":"2.2%","severity":"common","organSystem":""},{"effect":"Increased glucose","drugRate":"1.8%","severity":"common","organSystem":""},{"effect":"Nausea","drugRate":"1.4%","severity":"common","organSystem":""},{"effect":"Abnormal dreams","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Allergic reaction","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Anorexia","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Asthenia","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Asthma","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Coagulation time increased","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Constipation","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Dizziness","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Dry mouth","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Eructation","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Face edema","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Fever","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Flatulence","drugRate":"0.5%","severity":"common","organSystem":""},{"effect":"Fungal infection","drugRate":"0.5%","severity":"common","organSystem":""}],"contraindications":["Carnitine deficiency","Factor II deficiency","Impaired renal function disorder","Pseudomembranous enterocolitis"],"specialPopulations":{"Pregnancy":"Pregnancy Category B. Cefditoren pivoxil was not teratogenic up to the highest doses tested in rats and rabbits.","Geriatric use":"No clinically significant differences in effectiveness or safety were observed between older and younger patients. No dose adjustments are necessary in geriatric patients with normal (for their age) renal function.","Paediatric use":"Use of cefditoren pivoxil is not recommended for pediatric patients less than 12 years of age."},"seriousAdverseEvents":[{"effect":"Pseudomembranous colitis","drugRate":"0.5%","severity":"serious"},{"effect":"Anaphylaxis","drugRate":"","severity":"serious"},{"effect":"Stevens-Johnson syndrome","drugRate":"","severity":"serious"},{"effect":"Toxic epidermal necrolysis","drugRate":"","severity":"serious"},{"effect":"Serum sickness-like reaction","drugRate":"","severity":"serious"},{"effect":"Erythema multiforme","drugRate":"","severity":"serious"},{"effect":"Aplastic anemia","drugRate":"","severity":"serious"},{"effect":"Hemolytic anemia","drugRate":"","severity":"serious"},{"effect":"Toxic nephropathy","drugRate":"","severity":"serious"},{"effect":"Seizures","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Vansen Pharma","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CEFDITOREN PIVOXIL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:41:20.004190+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:41:27.952700+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFDITOREN PIVOXIL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:41:28.613611+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Bacterial penicillin-binding protein inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:41:29.176013+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL454446/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:41:29.064007+00:00"}},"allNames":"cefditoren pivoxyl","offLabel":[],"synonyms":["cefditoren pivoxil","cefditoren pivaloyloxymethyl ester","cefditoren pivoxyl"],"timeline":[{"date":"2001-08-29","type":"positive","source":"DrugCentral","milestone":"FDA approval (Vansen Pharma)"}],"aiSummary":"Cefditoren Pivoxil is a cephalosporin antibacterial drug, originally developed and currently owned by Vansen Pharma. It was FDA-approved in 2001 for various respiratory infections, including acute exacerbation of chronic bronchitis and bacterial pneumonia. As an off-patent drug, it is no longer protected by active patents, but there are currently no generic manufacturers. Cefditoren Pivoxil is a small molecule that targets a range of bacterial pathogens, including Haemophilus influenzae and Staphylococcus aureus. It is used to treat infections caused by these bacteria.","brandName":"Cefditoren Pivoxyl","ecosystem":[{"indication":"Acute exacerbation of chronic bronchitis","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azithromycin","slug":"azithromycin","company":""},{"name":"cefixime","slug":"cefixime","company":""}],"globalPrevalence":null},{"indication":"Bacterial pneumonia","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azithromycin","slug":"azithromycin","company":""}],"globalPrevalence":null},{"indication":"Haemophilus Influenzae Chronic Bronchitis","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth 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Hlthcare"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"Cephalosporin Antibacterial","explanation":"","oneSentence":"","technicalDetail":"Cefditoren Pivoxil exerts its antibacterial effect by competitively inhibiting the action of penicillin-binding proteins (PBPs) that are essential for bacterial cell wall synthesis, ultimately leading to the disruption of the bacterial cell wall and cell lysis."},"commercial":{"launchDate":"2001","_launchSource":"DrugCentral (FDA 2001-08-29, VANSEN PHARMA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/534","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CEFDITOREN%20PIVOXIL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFDITOREN 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