{"id":"cefbuperazone","rwe":[],"tags":[{"label":"cefbuperazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DC13","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["cefbuperazone"],"offLabel":[],"synonyms":["cefbuperazone"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cefbuperazone","explanation":"Imagine the bacterial cell wall as a brick wall. Cefbuperazone blocks the enzymes that help hold the bricks together, causing the wall to weaken and eventually collapse. This ultimately leads to the death of the bacterial cell.","oneSentence":"Cefbuperazone works by binding to penicillin-binding proteins in bacterial cell walls, preventing them from forming a strong bond and ultimately leading to cell lysis.","technicalDetail":"Cefbuperazone exerts its antibacterial effect by inhibiting the transpeptidase activity of penicillin-binding proteins (PBPs), which are essential for the cross-linking of peptidoglycan layers in the bacterial cell wall."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3072","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFBUPERAZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:12:43.822520","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:55.830190+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"cefoxitin","drugSlug":"cefoxitin","fdaApproval":"1978-10-18","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefuroxime","drugSlug":"cefuroxime","fdaApproval":"1983-10-19","genericCount":10,"patentStatus":"Off-patent — generic 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hours","clearance":"1.1 mL/min/kg","volumeOfDistribution":"0.19 L/kg"},"publicationCount":106,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01DC13","allCodes":["J01DC13"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"CEFBUPERAZONE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CEFBUPERAZONE is a small molecule with multiple synonyms, including BMY-25182 and CEFBUPERAZONE SODIUM.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:55.830190+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}