{"id":"cefazedone","rwe":[{"pmid":"39459320","year":"2024","title":"Crosslinked Biodegradable Hybrid Hydrogels Based on Poly(ethylene glycol) and Gelatin for Drug Controlled Release.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"38960739","year":"2024","title":"Nationwide Analysis of Antimicrobial Prescription in Korean Hospitals between 2018 and 2021: The 2023 KONAS Report.","finding":"","journal":"Infection & chemotherapy","studyType":"Clinical Study"},{"pmid":"34567348","year":"2021","title":"Risk factors of beta-lactam anaphylaxis in Korea: A 6-year multicenter retrospective adult case-control study.","finding":"","journal":"The World Allergy Organization journal","studyType":"Clinical Study"},{"pmid":"32916619","year":"2020","title":"Coupling-oxidation process promoted ring-opening degradation of 2-mecapto-5-methyl-1,3,4-thiadizaole in wastewater.","finding":"","journal":"Water research","studyType":"Clinical Study"},{"pmid":"31124960","year":"2019","title":"Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea.","finding":"","journal":"Medicine","studyType":"Clinical Study"}],"tags":[{"label":"cefazedone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DB06","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"refosporen","offLabel":[],"synonyms":["cefazedone sodium","EMD30087","cefazedone","refosporen"],"timeline":[],"brandName":"Refosporen","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cefazedone","explanation":"Imagine the bacterial cell wall like a brick wall. Refosporen blocks the enzymes that help build the wall, causing the wall to weaken and eventually collapse, leading to the death of the bacterial cell.","oneSentence":"Refosporen works by inhibiting the enzymes responsible for building the bacterial cell wall, ultimately leading to bacterial cell death.","technicalDetail":"Refosporen exerts its antibacterial effect by inhibiting the transpeptidase enzymes responsible for cross-linking peptidoglycan chains in the bacterial cell wall, ultimately disrupting cell wall synthesis and leading to cell lysis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3071","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFAZEDONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:18:23.539089","biosimilars":[],"competitors":[{"drugName":"cefalexin","drugSlug":"cefalexin","fdaApproval":"1971-01-04","relationship":"same-class"},{"drugName":"cefalotin","drugSlug":"cefalotin","fdaApproval":"1974-12-18","relationship":"same-class"},{"drugName":"cefazolin","drugSlug":"cefazolin","fdaApproval":"1973-10-04","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefadroxil","drugSlug":"cefadroxil","fdaApproval":"1978-02-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefapirin","drugSlug":"cefapirin","fdaApproval":"1974-03-12","relationship":"same-class"},{"drugName":"cefradine","drugSlug":"cefradine","fdaApproval":"1974-08-19","relationship":"same-class"}],"genericName":"cefazedone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cefalexin","brandName":"cefalexin","genericName":"cefalexin","approvalYear":"1971","relationship":"same-class"},{"drugId":"cefalotin","brandName":"cefalotin","genericName":"cefalotin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefazolin","brandName":"cefazolin","genericName":"cefazolin","approvalYear":"1973","relationship":"same-class"},{"drugId":"cefadroxil","brandName":"cefadroxil","genericName":"cefadroxil","approvalYear":"1978","relationship":"same-class"},{"drugId":"cefapirin","brandName":"cefapirin","genericName":"cefapirin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefradine","brandName":"cefradine","genericName":"cefradine","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010926","UNII":"7Y86X0D799","CHEBI":"CHEBI:131731","INN_ID":"4117","UMLSCUI":"C0054999","ChEMBL_ID":"CHEMBL2107636","KEGG_DRUG":"D07237","DRUGBANK_ID":"DB13778","PUBCHEM_CID":"71736","IUPHAR_LIGAND_ID":"12203","SECONDARY_CAS_RN":"63521-15-3","MESH_SUPPLEMENTAL_RECORD_UI":"C021341"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.91 hours","clearance":"0.95 mL/min/kg","volumeOfDistribution":"0.13 L/kg"},"publicationCount":60,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01DB06","allCodes":["J01DB06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Oct 19","pmid":"39459320","title":"Crosslinked Biodegradable Hybrid Hydrogels Based on Poly(ethylene glycol) and Gelatin for Drug Controlled Release.","journal":"Molecules (Basel, Switzerland)"},{"date":"2024 Jun","pmid":"38960739","title":"Nationwide Analysis of Antimicrobial Prescription in Korean Hospitals between 2018 and 2021: The 2023 KONAS Report.","journal":"Infection & chemotherapy"},{"date":"2021 Sep","pmid":"34567348","title":"Risk factors of beta-lactam anaphylaxis in Korea: A 6-year multicenter retrospective adult case-control study.","journal":"The World Allergy Organization journal"},{"date":"2020 Nov 1","pmid":"32916619","title":"Coupling-oxidation process promoted ring-opening degradation of 2-mecapto-5-methyl-1,3,4-thiadizaole in wastewater.","journal":"Water research"},{"date":"2019 May","pmid":"31124960","title":"Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea.","journal":"Medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Refosporen is a small molecule. It is also known by the synonyms CEFAZEDONA, CEFAZEDONE, and CEFAZEDONE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}