{"id":"cefatrizine","rwe":[{"pmid":"41532756","year":"2026","title":"Plasmids of the multidrug-resistant Citrobacter portucalensis KOS1-1 strain isolated from a wastewater treatment plant harbor antibiotic resistance genes and gene clusters involved in carbon metabolism.","finding":"","journal":"Microbiology spectrum","studyType":"Clinical Study"},{"pmid":"40725000","year":"2025","title":"In Silico Evaluation of Quinolone-Triazole and Conazole-Triazole Hybrids as Promising Antimicrobial and Anticancer Agents.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"36334453","year":"2022","title":"1,2,3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens.","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"35547394","year":"2022","title":"Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications.","finding":"","journal":"Frontiers in molecular biosciences","studyType":"Clinical Study"},{"pmid":"34766892","year":"2022","title":"The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020- Present).","finding":"","journal":"Current topics in medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"cefatrizine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DB07","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cepticol","offLabel":[],"synonyms":["cefatrizine","cefaperos","cephatrizin","cephatrizine","cepticol"],"timeline":[],"brandName":"Cepticol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cefatrizine","explanation":"Imagine your body's cells are like houses, and the bacterial cell wall is like the walls of those houses. Cefatrizine blocks the construction of these walls, making it difficult for bacteria to grow and multiply. This ultimately leads to the death of the bacterial cells.","oneSentence":"Cefatrizine works by inhibiting the enzymes responsible for bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Cefatrizine exerts its antibacterial effects by inhibiting the transpeptidase enzymes responsible for cross-linking peptidoglycan chains in the bacterial cell wall, ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/529","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CEFATRIZINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFATRIZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:12:40.392910","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:08.320956+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"cefalexin","drugSlug":"cefalexin","fdaApproval":"1971-01-04","relationship":"same-class"},{"drugName":"cefalotin","drugSlug":"cefalotin","fdaApproval":"1974-12-18","relationship":"same-class"},{"drugName":"cefazolin","drugSlug":"cefazolin","fdaApproval":"1973-10-04","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefadroxil","drugSlug":"cefadroxil","fdaApproval":"1978-02-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefapirin","drugSlug":"cefapirin","fdaApproval":"1974-03-12","relationship":"same-class"},{"drugName":"cefradine","drugSlug":"cefradine","fdaApproval":"1974-08-19","relationship":"same-class"}],"genericName":"cefatrizine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cefalexin","brandName":"cefalexin","genericName":"cefalexin","approvalYear":"1971","relationship":"same-class"},{"drugId":"cefalotin","brandName":"cefalotin","genericName":"cefalotin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefazolin","brandName":"cefazolin","genericName":"cefazolin","approvalYear":"1973","relationship":"same-class"},{"drugId":"cefadroxil","brandName":"cefadroxil","genericName":"cefadroxil","approvalYear":"1978","relationship":"same-class"},{"drugId":"cefapirin","brandName":"cefapirin","genericName":"cefapirin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefradine","brandName":"cefradine","genericName":"cefradine","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03877289","phase":"PHASE4","title":"Efficacy of Oxybutynin in Paediatric Cystitis","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2008-10","conditions":["Cystitis"],"enrollment":81,"completionDate":"2014-07"},{"nctId":"NCT04226560","phase":"NA","title":"Performance and Safety of Silicone Hydrogel Soft Contact Lenses","status":"UNKNOWN","sponsor":"ApexLens Co., Ltd.","startDate":"2020-04-20","conditions":["Myopia"],"enrollment":65,"completionDate":"2021-05-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166880","NDDF":"004202","UNII":"8P4W949T8K","CHEBI":"CHEBI:131730","INN_ID":"3839","RXNORM":"2179","UMLSCUI":"C0007545","ChEMBL_ID":"CHEMBL1095284","KEGG_DRUG":"D02406","DRUGBANK_ID":"DB13266","PUBCHEM_CID":"6410758","SNOMEDCT_US":"50020121000188105","IUPHAR_LIGAND_ID":"12204","MESH_DESCRIPTOR_UI":"D002436"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.2 hours","clearance":"3.3 mL/min/kg","bioavailability":"66%","fractionUnbound":"0.4%","volumeOfDistribution":"0.22 L/kg"},"publicationCount":114,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01DB07","allCodes":["J01DB07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 3","pmid":"41532756","title":"Plasmids of the multidrug-resistant Citrobacter portucalensis KOS1-1 strain isolated from a wastewater treatment plant harbor antibiotic resistance genes and gene clusters involved in carbon metabolism.","journal":"Microbiology spectrum"},{"date":"2025 Jul 14","pmid":"40725000","title":"In Silico Evaluation of Quinolone-Triazole and Conazole-Triazole Hybrids as Promising Antimicrobial and Anticancer Agents.","journal":"International journal of molecular sciences"},{"date":"2022 Dec 15","pmid":"36334453","title":"1,2,3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens.","journal":"European journal of medicinal chemistry"},{"date":"2022","pmid":"35547394","title":"Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications.","journal":"Frontiers in molecular biosciences"},{"date":"2022","pmid":"34766892","title":"The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020- Present).","journal":"Current topics in medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cefatrizine, also known as Cepticol, is a small molecule antibiotic in the cefatrizine class. Its mechanism of action involves inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death. However, due to the lack of available information, its target and approved indications are unknown. The commercial status of cefatrizine is also unclear, with no information available on its patent status or generic manufacturers. Further research is needed to determine its safety profile and potential side effects.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:08.320956+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}