{"id":"cefaloridine","rwe":[],"tags":[{"label":"cefaloridine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cefaloridin","offLabel":[],"synonyms":["cephaloridine","cefaloridine","cefaloridin","cephalomycine"],"timeline":[],"brandName":"Cefaloridin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cefaloridine","explanation":"Imagine the bacterial cell wall as a brick wall. Cefaloridine blocks the enzymes that help build the wall, causing the wall to weaken and eventually collapse, killing the bacteria. This mechanism is crucial for treating bacterial infections.","oneSentence":"Cefaloridine works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Cefaloridine exerts its antibacterial effect by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, inhibiting the transpeptidation reaction that cross-links peptidoglycan chains, ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/573","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=cefaloridine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=cefaloridine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:12:33.395245","biosimilars":[],"competitors":[{"drugName":"cefalexin","drugSlug":"cefalexin","fdaApproval":"1971-01-04","relationship":"same-class"},{"drugName":"cefalotin","drugSlug":"cefalotin","fdaApproval":"1974-12-18","relationship":"same-class"},{"drugName":"cefazolin","drugSlug":"cefazolin","fdaApproval":"1973-10-04","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefadroxil","drugSlug":"cefadroxil","fdaApproval":"1978-02-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefapirin","drugSlug":"cefapirin","fdaApproval":"1974-03-12","relationship":"same-class"},{"drugName":"cefradine","drugSlug":"cefradine","fdaApproval":"1974-08-19","relationship":"same-class"}],"genericName":"cefaloridine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cefalexin","brandName":"cefalexin","genericName":"cefalexin","approvalYear":"1971","relationship":"same-class"},{"drugId":"cefalotin","brandName":"cefalotin","genericName":"cefalotin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefazolin","brandName":"cefazolin","genericName":"cefazolin","approvalYear":"1973","relationship":"same-class"},{"drugId":"cefadroxil","brandName":"cefadroxil","genericName":"cefadroxil","approvalYear":"1978","relationship":"same-class"},{"drugId":"cefapirin","brandName":"cefapirin","genericName":"cefapirin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefradine","brandName":"cefradine","genericName":"cefradine","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03877289","phase":"PHASE4","title":"Efficacy of Oxybutynin in Paediatric Cystitis","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2008-10","conditions":["Cystitis"],"enrollment":81,"completionDate":"2014-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000008008","NDDF":"002713","UNII":"LVZ1VC61HB","CHEBI":"CHEBI:3537","INN_ID":"1910","RXNORM":"2233","UMLSCUI":"C0007727","ChEMBL_ID":"CHEMBL316157","KEGG_DRUG":"D01075","DRUGBANK_ID":"DB09008","PUBCHEM_CID":"5773","SNOMEDCT_US":"28588009","IUPHAR_LIGAND_ID":"12189","MESH_DESCRIPTOR_UI":"D002509"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.5 hours","clearance":"3.3 mL/min/kg","fractionUnbound":"0.8%","volumeOfDistribution":"0.46 L/kg"},"publicationCount":22,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01DB02","allCodes":["J01DB02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Cefaloridin is a small molecule, semisynthetic derivative of cephalosporin C, a type of Beta lactam antibiotic similar to penicillin. Its chemical structure consists of cephems, carboxyl groups, and a pyridinium ring.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}