{"id":"ce-224-535","safety":{"commonSideEffects":[{"rate":"40-50%","effect":"Neutropenia"},{"rate":"30-40%","effect":"Thrombocytopenia"},{"rate":"20-30%","effect":"Anemia"}]},"_chembl":{"chemblId":"CHEMBL1823817","moleculeType":"Small molecule","molecularWeight":"480.95"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"BTK is a key component in the B-cell receptor signaling pathway, and its inhibition has been shown to be effective in treating various B-cell malignancies. CE-224,535 works by selectively binding to the ATP-binding site of BTK, thereby inhibiting its activity and leading to the death of cancer cells.","oneSentence":"CE-224,535 is a small molecule inhibitor of the Bruton's tyrosine kinase (BTK) enzyme.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:50:18.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsed or refractory mantle cell lymphoma"},{"name":"Relapsed or refractory marginal zone lymphoma"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Part 1;Treatment A","Part 1;Treatment B","Part 1;Treatment C","Part 1;Treatment D","Part 2;Treatment E"],"phase":"phase_2","status":"active","brandName":"CE-224,535","genericName":"CE-224,535","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CE-224,535 is a small molecule inhibitor of the Bruton's tyrosine kinase (BTK) enzyme. Used for Relapsed or refractory mantle cell lymphoma, Relapsed or refractory marginal zone lymphoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}