{"id":"cd-4-guided-therapy-interruption","safety":{"commonSideEffects":[{"rate":null,"effect":"Viral rebound"},{"rate":null,"effect":"CD4 decline"},{"rate":null,"effect":"Opportunistic infections"},{"rate":null,"effect":"Immune reconstitution inflammatory syndrome (IRIS)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This approach uses CD4+ T cell counts as a biomarker to guide when to interrupt antiretroviral therapy (ART) in HIV-infected patients. The strategy aims to minimize cumulative antiretroviral drug exposure and associated toxicities while relying on the patient's residual immune function to control viral replication during treatment interruption periods. Therapy is resumed when CD4 counts decline below a predetermined threshold.","oneSentence":"CD4-guided therapy interruption is a treatment strategy that involves periodically stopping antiretroviral therapy in HIV patients based on CD4+ T cell count thresholds to reduce long-term drug exposure while maintaining immune control.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:29:15.919Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV infection (CD4-guided structured treatment interruption)"}]},"trialDetails":[{"nctId":"NCT00414518","phase":"NA","title":"Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 Infection","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2007-01","conditions":"HIV Infections","enrollment":16},{"nctId":"NCT00433056","phase":"PHASE3","title":"Long Term Treatment Interruptions","status":"COMPLETED","sponsor":"A.O. Ospedale Papa Giovanni XXIII","startDate":"2004-01","conditions":"HIV Infections, AIDS","enrollment":320},{"nctId":"NCT00646984","phase":"PHASE4","title":"Strategies of Interruption/Reinitiation of Antiretroviral Therapy in HIV-Infected Patients With Lipodystrophy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2002-01","conditions":"HIV-Associated Lipodystrophy Syndrome","enrollment":147},{"nctId":"NCT00113126","phase":"NA","title":"Staccato: A Trial of CD4 Guided Treatment Interruption, Compared to Continuous Treatment, for HIV Infection","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2002-01","conditions":"HIV Infection, AIDS","enrollment":526},{"nctId":"NCT00310245","phase":"PHASE3","title":"BASTA Study on STI in HIV Infected Patients","status":"COMPLETED","sponsor":"A.O. Ospedale Papa Giovanni XXIII","startDate":"2000-11","conditions":"HIV Infection","enrollment":130}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"CD-4 guided therapy interruption","genericName":"CD-4 guided therapy interruption","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CD4-guided therapy interruption is a treatment strategy that involves periodically stopping antiretroviral therapy in HIV patients based on CD4+ T cell count thresholds to reduce long-term drug exposure while maintaining immune control. Used for HIV infection (CD4-guided structured treatment interruption).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}