{"id":"cck-kinevac","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain or cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Kinevac is a synthetic form of cholecystokinin, a naturally occurring hormone that acts on CCK-A receptors located on gallbladder smooth muscle and pancreatic acinar cells. When administered intravenously, it mimics the physiological effects of endogenous CCK, causing gallbladder contraction and promoting pancreatic enzyme secretion. This mechanism makes it useful as a diagnostic agent to assess gallbladder function and pancreatic response.","oneSentence":"CCK (cholecystokinin) is a synthetic peptide hormone that binds to CCK receptors to stimulate gallbladder contraction and pancreatic secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:24:25.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diagnostic agent for assessment of gallbladder function and biliary dyskinesia"},{"name":"Stimulation of pancreatic secretion for diagnostic pancreatic function testing"}]},"trialDetails":[{"nctId":"NCT07019519","phase":"NA","title":"POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS","status":"RECRUITING","sponsor":"University of Copenhagen","startDate":"2025-03-15","conditions":"Postural Orthostatic Tachycardia Syndrome (POTS), Healthy","enrollment":30},{"nctId":"NCT04567667","phase":"PHASE1","title":"Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"2020-10-15","conditions":"Healthy Volunteers","enrollment":9},{"nctId":"NCT00706381","phase":"PHASE3","title":"Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2008-06-23","conditions":"Healthy Volunteers","enrollment":31},{"nctId":"NCT02496221","phase":"PHASE4","title":"A Study Evaluating the Effect of Albiglutide on Gallbladder Emptying in Healthy Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-06-11","conditions":"Diabetes Mellitus, Type 2","enrollment":20},{"nctId":"NCT00685477","phase":"NA","title":"Dose Response of Intravenous Sincalide(CCK-8) for Gallbladder Emptying","status":"COMPLETED","sponsor":"Temple University","startDate":"2008-05","conditions":"Healthy","enrollment":60},{"nctId":"NCT01656057","phase":"NA","title":"The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion","status":"COMPLETED","sponsor":"Filip Krag Knop","startDate":"2012-07","conditions":"To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion","enrollment":10},{"nctId":"NCT00004414","phase":"NA","title":"Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis","status":"COMPLETED","sponsor":"University of Michigan","startDate":"1997-09","conditions":"Cholestasis","enrollment":252},{"nctId":"NCT00737295","phase":"NA","title":"Ultrasound for Diagnosis of Biliary Dyskinesia","status":"TERMINATED","sponsor":"Texas Tech University Health Sciences Center","startDate":"2008-05","conditions":"Biliary Dyskinesia","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"CCK (Kinevac)","genericName":"CCK (Kinevac)","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CCK (cholecystokinin) is a synthetic peptide hormone that binds to CCK receptors to stimulate gallbladder contraction and pancreatic secretion. Used for Diagnostic agent for assessment of gallbladder function and biliary dyskinesia, Stimulation of pancreatic secretion for diagnostic pancreatic function testing.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}