{"id":"cathine","rwe":[{"pmid":"41846256","year":"2026","title":"In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses.","finding":"","journal":"Journal of forensic sciences","studyType":"Clinical Study"},{"pmid":"40760747","year":"2025","title":"Unveiling the Potential Role of Cathinone and Cathine Compounds in Alzheimer's Disease: Predictive Insights.","finding":"","journal":"Current Alzheimer research","studyType":"Clinical Study"},{"pmid":"40554466","year":"2025","title":"Sex-specific effects of appetite suppressants on stereotypy in rats.","finding":"","journal":"PloS one","studyType":"Clinical Study"},{"pmid":"40004630","year":"2025","title":"Understanding the Intricacies of Khat-Associated Cardiovascular Disease.","finding":"","journal":"Journal of clinical medicine","studyType":"Clinical Study"},{"pmid":"39034439","year":"2024","title":"The stimulant cathine from Khat causes tachycardia indirectly in the rat.","finding":"","journal":"Basic & clinical pharmacology & toxicology","studyType":"Clinical Study"}],"tags":[{"label":"cathine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A08AA07","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Obesity Agents","category":"pharmacology"},{"label":"Appetite Depressants","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"norpseudoephedrine","offLabel":[],"synonyms":["(+)-Norpseudoephedrine","norpseudoephedrine","cathine","pseudonorephedrine"],"timeline":[],"brandName":"Norpseudoephedrine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cathine","explanation":"Imagine your brain is a busy office, and norpseudoephedrine is like a super-caffeine that helps keep the office workers (neurons) going all day long. It does this by increasing the amount of certain chemicals in the brain that help you feel more alert and awake. This can be helpful for people who need a energy boost, but it can also have negative effects if taken in excess.","oneSentence":"Norpseudoephedrine works by stimulating the central nervous system, increasing alertness and energy.","technicalDetail":"Norpseudoephedrine acts as a norepinephrine-dopamine reuptake inhibitor, increasing the levels of these neurotransmitters in the synaptic cleft and enhancing their effects on the central nervous system."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3389","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CATHINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:16:05.205224","biosimilars":[],"competitors":[{"drugName":"phentermine","drugSlug":"phentermine","fdaApproval":"1959-05-04","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenfluramine","drugSlug":"fenfluramine","fdaApproval":"2020-06-25","patentExpiry":"Nov 3, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diethylpropion","drugSlug":"diethylpropion","fdaApproval":"1959-08-06","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mazindol","drugSlug":"mazindol","fdaApproval":"1973-06-14","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"sibutramine","drugSlug":"sibutramine","fdaApproval":"1997-11-22","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"lorcaserin","drugSlug":"lorcaserin","fdaApproval":"2012-06-27","relationship":"same-class"},{"drugName":"setmelanotide","drugSlug":"setmelanotide","fdaApproval":"2020-11-25","patentExpiry":"Oct 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"topiramate","drugSlug":"topiramate","fdaApproval":"1996-12-24","patentExpiry":"Nov 16, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ephedrine","drugSlug":"ephedrine","fdaApproval":"","patentExpiry":"May 16, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"bupropion","drugSlug":"bupropion","fdaApproval":"1985-12-30","patentExpiry":"Jun 27, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"naltrexone","drugSlug":"naltrexone","fdaApproval":"1984-11-20","patentExpiry":"Oct 15, 2029","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"cathine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phentermine","brandName":"phentermine","genericName":"phentermine","approvalYear":"1959","relationship":"same-class"},{"drugId":"fenfluramine","brandName":"fenfluramine","genericName":"fenfluramine","approvalYear":"2020","relationship":"same-class"},{"drugId":"diethylpropion","brandName":"diethylpropion","genericName":"diethylpropion","approvalYear":"1959","relationship":"same-class"},{"drugId":"mazindol","brandName":"mazindol","genericName":"mazindol","approvalYear":"1973","relationship":"same-class"},{"drugId":"sibutramine","brandName":"sibutramine","genericName":"sibutramine","approvalYear":"1997","relationship":"same-class"},{"drugId":"lorcaserin","brandName":"lorcaserin","genericName":"lorcaserin","approvalYear":"2012","relationship":"same-class"},{"drugId":"setmelanotide","brandName":"setmelanotide","genericName":"setmelanotide","approvalYear":"2020","relationship":"same-class"},{"drugId":"topiramate","brandName":"topiramate","genericName":"topiramate","approvalYear":"1996","relationship":"same-class"},{"drugId":"ephedrine","brandName":"ephedrine","genericName":"ephedrine","approvalYear":"","relationship":"same-class"},{"drugId":"bupropion","brandName":"bupropion","genericName":"bupropion","approvalYear":"1985","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007019","UNII":"E1L4ZW2F8O","CHEBI":"CHEBI:4109","INN_ID":"4952","RXNORM":"32022","UMLSCUI":"C0069021","ChEMBL_ID":"CHEMBL1412041","KEGG_DRUG":"D07627","DRUGBANK_ID":"DB01486","PUBCHEM_CID":"441457","SNOMEDCT_US":"96257008","SECONDARY_CAS_RN":"36393-56-3","MESH_SUPPLEMENTAL_RECORD_UI":"C005331"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":129,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"A08AA07","allCodes":["A08AA07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 17","pmid":"41846256","title":"In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses.","journal":"Journal of forensic sciences"},{"date":"2025","pmid":"40760747","title":"Unveiling the Potential Role of Cathinone and Cathine Compounds in Alzheimer's Disease: Predictive Insights.","journal":"Current Alzheimer research"},{"date":"2025","pmid":"40554466","title":"Sex-specific effects of appetite suppressants on stereotypy in rats.","journal":"PloS one"},{"date":"2025 Feb 9","pmid":"40004630","title":"Understanding the Intricacies of Khat-Associated Cardiovascular Disease.","journal":"Journal of clinical medicine"},{"date":"2024 Sep","pmid":"39034439","title":"The stimulant cathine from Khat causes tachycardia indirectly in the rat.","journal":"Basic & clinical pharmacology & toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norpseudoephedrine, also known as cathine, is a small molecule drug of the cathine class. Its original development and current ownership are not specified. The target of norpseudoephedrine is unknown, and it is not FDA-approved for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety considerations. Further research is needed to fully understand this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}