{"id":"carvedilol-ir-25mg-qd","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Dizziness"},{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5","effect":"Hyperglycemia"},{"rate":"5-10","effect":"Erectile dysfunction"}]},"_chembl":{"chemblId":"CHEMBL1201167","moleculeType":"Small molecule","molecularWeight":"504.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carvedilol blocks beta-1, beta-2, and alpha-1 adrenergic receptors, reducing sympathetic nervous system activity on the heart and blood vessels. This dual action decreases heart rate and contractility while causing vasodilation, leading to reduced blood pressure and improved cardiac efficiency. It is commonly used in heart failure and hypertension management.","oneSentence":"Carvedilol is a non-selective beta-adrenergic receptor antagonist with alpha-1 blocking activity that reduces heart rate, blood pressure, and cardiac workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:00.587Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heart failure with reduced ejection fraction"},{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Post-myocardial infarction"}]},"trialDetails":[{"nctId":"NCT01756430","phase":"PHASE3","title":"Efficacy and Safety of Carvedilol SR Versus Carvedilol IR in Patients With Essential Hypertension","status":"COMPLETED","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2012-12","conditions":"Hypertension","enrollment":238}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dilatrend IR"],"phase":"phase_3","status":"active","brandName":"Carvedilol IR 25mg, QD","genericName":"Carvedilol IR 25mg, QD","companyName":"Chong Kun Dang Pharmaceutical","companyId":"chong-kun-dang-pharmaceutical","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carvedilol is a non-selective beta-adrenergic receptor antagonist with alpha-1 blocking activity that reduces heart rate, blood pressure, and cardiac workload. Used for Heart failure with reduced ejection fraction, Hypertension, Angina pectoris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}