{"id":"carvedilol-cr-lisinopril","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Hyperkalemia"}]},"_chembl":{"chemblId":"CHEMBL419213","moleculeType":"Small molecule","molecularWeight":"441.53"},"_fixedAt":"2026-03-30T13:33:46.815780","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carvedilol blocks beta-1, beta-2, and alpha-1 adrenergic receptors, reducing heart rate, contractility, and peripheral vascular resistance. Lisinopril inhibits angiotensin-converting enzyme, preventing formation of angiotensin II and reducing vasoconstriction and aldosterone secretion. Together, they provide complementary hemodynamic benefits for heart failure and hypertension management.","oneSentence":"Carvedilol CR (a non-selective beta-blocker with alpha-blocking activity) combined with Lisinopril (an ACE inhibitor) reduces blood pressure and cardiac workload through dual pathway inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:59.544Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heart failure with reduced ejection fraction"},{"name":"Hypertension"},{"name":"Post-myocardial infarction management"}]},"_fixedFields":["pubmed(2)"],"trialDetails":[{"nctId":"NCT00430040","phase":"PHASE4","title":"Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI.","status":"TERMINATED","sponsor":"University at Buffalo","startDate":"2007-02","conditions":"Diabetes Mellitus, Type 2, Hypertension","enrollment":14},{"nctId":"NCT00657241","phase":"PHASE3","title":"Cardioprotective Benefits of Carvedilol-CR or Valsartan Added to Lisinopril","status":"COMPLETED","sponsor":"State University of New York at Buffalo","startDate":"2008-04","conditions":"Hypertension","enrollment":30},{"nctId":"NCT01009918","phase":"PHASE2","title":"Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2010-03","conditions":"Breast Cancer, Cardiac Toxicity","enrollment":468},{"nctId":"NCT00553969","phase":"PHASE1, PHASE2","title":"Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2007-11","conditions":"Pre-hypertension","enrollment":101},{"nctId":"NCT00508365","phase":"PHASE1","title":"Evaluation of Potential for Orthostatic Hypotension in Elderly Hypertensives","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-09-25","conditions":"Hypertension","enrollment":62},{"nctId":"NCT00624065","phase":"PHASE3","title":"Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-03","conditions":"Hypertension","enrollment":348},{"nctId":"NCT00347360","phase":"PHASE3","title":"The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-07","conditions":"Hypertension","enrollment":654},{"nctId":"NCT00108082","phase":"PHASE3","title":"The CLEVER Study - Coreg And Left Ventricular Mass Regression","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-01","conditions":"Hypertrophy, Left Ventricular","enrollment":287},{"nctId":"NCT00459056","phase":"PHASE3","title":"The Vascular Effects of Carvedilol Controlled Release (CR) in Abdominally Obese Hypertensive Patients","status":"COMPLETED","sponsor":"St. Paul Heart Clinic","startDate":"2007-04","conditions":"Abdominal Obesity, Hypertension","enrollment":25},{"nctId":"NCT00537043","phase":"PHASE1","title":"A Study to Compare COREG CR to COREG CR Fixed-dose Combination in Patients With High Blood Pressure","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-10","conditions":"Hypertension","enrollment":24},{"nctId":"NCT00552708","phase":"PHASE1","title":"A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-09","conditions":"Hypertension","enrollment":55},{"nctId":"NCT00557128","phase":"PHASE1","title":"Study to Examine the Effect of Food on the Pharmacokinetics of the Fixed Dose Combination of COREG CR and Lisinopril.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-11","conditions":"Hypertension","enrollment":24},{"nctId":"NCT00549510","phase":"PHASE1","title":"Study to Investigate Dose Proportionality of the Fixed Dose Combination of COREG CR and Lisinopril.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-10","conditions":"Hypertension","enrollment":29},{"nctId":"NCT00556920","phase":"PHASE1","title":"Study to Demonstrate the Bioequivalence of the Fixed Dose Combination of COREG CR™ and Lisinopril to Its Components","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-10","conditions":"Hypertension","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"recentPublications":[{"date":"2010 Nov-Dec","pmid":"20980215","title":"Importance of blood pressure control in left ventricular mass regression.","journal":"Journal of the American Society of Hypertension : JASH"},{"date":"2010 Sep","pmid":"20883227","title":"Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.","journal":"Journal of clinical hypertension (Greenwich, Conn.)"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prinivil","Coreg"],"phase":"phase_3","status":"active","brandName":"Carvedilol CR + Lisinopril","genericName":"Carvedilol CR + Lisinopril","companyName":"St. Paul Heart Clinic","companyId":"st-paul-heart-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carvedilol CR (a non-selective beta-blocker with alpha-blocking activity) combined with Lisinopril (an ACE inhibitor) reduces blood pressure and cardiac workload through dual pathway inhibition. Used for Heart failure with reduced ejection fraction, Hypertension, Post-myocardial infarction management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}