{"id":"carubicin","rwe":[{"pmid":"41082582","year":"2025","title":"Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds.","finding":"","journal":"PLoS pathogens","studyType":"Clinical Study"},{"pmid":"6546298","year":"1984","title":"Carminomycin. 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It is also known by other names, including Carminomycin Hydrochloride, Carubicin HCL, Carubicin Hydrochloride, and NSC-275649.","brandName":"Carminomicin I","ecosystem":[],"mechanism":{"target":"DNA topoisomerase 2-alpha","targets":[{"gene":"TOP2A","source":"DrugCentral","target":"DNA topoisomerase 2-alpha","protein":"DNA topoisomerase 2-alpha"}],"modality":"Small Molecule","drugClass":"carubicin","explanation":"Imagine your DNA as a twisted ladder. DNA topoisomerase 2-alpha is an enzyme that helps to unwind this ladder so that the cell can replicate. CARUBICIN blocks this enzyme, preventing the DNA from being unwound and ultimately leading to cell death.","oneSentence":"CARUBICIN works by binding to DNA topoisomerase 2-alpha, preventing the enzyme from unwinding DNA and leading to cell death.","technicalDetail":"CARUBICIN binds to the ATPase domain of DNA topoisomerase 2-alpha, inhibiting its ability to catalyze the cleavage of DNA and thereby preventing DNA replication and cell 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