{"id":"cartistem-debridement","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Knee effusion"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Immune reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CARTISTEM contains human mesenchymal stem cells that differentiate into chondrocytes and promote cartilage matrix regeneration. When administered following arthroscopic debridement of articular cartilage defects, the stem cells facilitate tissue repair and restore functional cartilage. The combination approach removes damaged tissue while simultaneously providing regenerative cellular therapy to promote healing.","oneSentence":"CARTISTEM is an allogeneic bone marrow-derived mesenchymal stem cell product that regenerates damaged cartilage tissue when combined with surgical debridement.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:34.041Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Articular cartilage defects of the knee (Grade 3-4 chondral lesions)"}]},"trialDetails":[{"nctId":"NCT07339111","phase":"PHASE3","title":"Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis","status":"RECRUITING","sponsor":"Medipost, Inc.","startDate":"2026-03-11","conditions":"Knee Cartilage Defects","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"CARTISTEM® + Debridement","genericName":"CARTISTEM® + Debridement","companyName":"Medipost, Inc.","companyId":"medipost-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"CARTISTEM is an allogeneic bone marrow-derived mesenchymal stem cell product that regenerates damaged cartilage tissue when combined with surgical debridement. Used for Articular cartilage defects of the knee (Grade 3-4 chondral lesions).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}