{"id":"carperitide","rwe":[{"pmid":"41310450","year":"2025","title":"Effect of carperitide on clinical outcomes among patients with acute heart failure: a meta-analysis of randomized and propensity‑matched studies.","finding":"","journal":"BMC cardiovascular disorders","studyType":"Clinical Study"},{"pmid":"41080765","year":"2025","title":"Effect of carperitide on mortality and ANP levels in acute heart failure: A systematic review and meta-analysis.","finding":"","journal":"American heart journal plus : cardiology research and practice","studyType":"Clinical Study"},{"pmid":"40922889","year":"2025","title":"Effect of Carperitide on Clinical Outcomes in Patients With Heart Failure: A Systematic Review and Meta-Analysis.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"39656827","year":"2025","title":"Effect of low-dose administration of carperitide for acute heart failure: the LASCAR-AHF trial.","finding":"","journal":"European heart journal. Acute cardiovascular care","studyType":"Clinical Study"},{"pmid":"38941956","year":"2024","title":"Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies.","finding":"","journal":"EBioMedicine","studyType":"Clinical Study"}],"tags":[{"label":"carperitide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Atrial natriuretic peptide receptor 1","category":"target"},{"label":"NPR1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{"safetySignals":[{"llr":110.247,"date":"","count":50,"signal":"Cardiac failure","source":"DrugCentral FAERS","actionTaken":"Reported 50 times (LLR=110)"},{"llr":66.926,"date":"","count":36,"signal":"Renal impairment","source":"DrugCentral FAERS","actionTaken":"Reported 36 times (LLR=67)"},{"llr":59.177,"date":"","count":17,"signal":"Hypernatraemia","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=59)"},{"llr":49.755,"date":"","count":14,"signal":"Cardiac failure chronic","source":"DrugCentral FAERS","actionTaken":"Reported 14 times (LLR=50)"},{"llr":47.772,"date":"","count":22,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=48)"},{"llr":36.814,"date":"","count":16,"signal":"Cerebral infarction","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=37)"}],"commonSideEffects":[{"effect":"Cardiac failure","drugRate":"LLR 110","severity":"common"},{"effect":"Renal impairment","drugRate":"LLR 67","severity":"common"},{"effect":"Hypernatraemia","drugRate":"LLR 59","severity":"common"},{"effect":"Hepatic function abnormal","drugRate":"LLR 48","severity":"common"},{"effect":"Cerebral infarction","drugRate":"LLR 37","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"atriopeptin","offLabel":[],"synonyms":["carperitide","human atrial natriuretic peptide","atriopeptin","carperitide (recombinant)"],"timeline":[],"aiSummary":"Atriopeptin, also known as carperitide, is a small molecule drug that targets the atrial natriuretic peptide receptor 1. It is used to treat certain heart conditions, although its exact approved indications are unknown. As a carperitide, it is a synthetic version of a naturally occurring peptide hormone. The commercial status of carperitide is unclear, and it may not be available as a generic medication. Key safety considerations include its short half-life of 0.22 hours.","brandName":"Atriopeptin","ecosystem":[],"mechanism":{"target":"Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor 1","targets":[{"gene":"NPR1","source":"DrugCentral","target":"Atrial natriuretic peptide receptor 1","protein":"Atrial natriuretic peptide receptor 1"}],"modality":"Peptide","drugClass":"carperitide","explanation":"Imagine your blood vessels are like a tight rubber band. When they're too tight, it's hard for blood to flow through. Carperitide helps to relax these blood vessels, making it easier for blood to flow and reducing the pressure on your heart.","oneSentence":"Carperitide works by mimicking the action of a naturally occurring hormone that helps to relax blood vessels and reduce blood pressure.","technicalDetail":"Carperitide binds to the atrial natriuretic peptide receptor 1 (NPR1), activating a signaling pathway that leads to the relaxation of vascular smooth muscle and a decrease in blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/515","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CARPERITIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CARPERITIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:12:44.733922","biosimilars":[],"competitors":[{"drugName":"glyceryl trinitrate","drugSlug":"glyceryl-trinitrate","fdaApproval":"1981-05-28","relationship":"same-target"},{"drugName":"isosorbide dinitrate","drugSlug":"isosorbide-dinitrate","fdaApproval":"1968-01-16","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"isosorbide 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