{"id":"caroxazone","rwe":[{"pmid":"2790290","year":"1989","title":"Effects of phenylethylamine on rat locomotor behavior and avoidance learning.","finding":"","journal":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas","studyType":"Clinical Study"},{"pmid":"3756328","year":"1986","title":"[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].","finding":"","journal":"Biulleten' eksperimental'noi biologii i meditsiny","studyType":"Clinical Study"},{"pmid":"6889985","year":"1982","title":"[Comparative pharmacological study of the antidepressants pyrazidol, inkazan, caroxazone and imipramine].","finding":"","journal":"Farmakologiia i toksikologiia","studyType":"Clinical Study"},{"pmid":"7046361","year":"1982","title":"Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials.","finding":"","journal":"Advances in biochemical psychopharmacology","studyType":"Clinical Study"},{"pmid":"6170295","year":"1981","title":"Studies on the mechanism of action of caroxazone, a new antidepressant drug.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"caroxazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Depressive disorder","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"timostenil","offLabel":[],"synonyms":["FI-6654","FI 6654","caroxazone","timostenil"],"timeline":[],"brandName":"Timostenil","ecosystem":[{"indication":"Depressive disorder","otherDrugs":[{"name":"amitriptyline","slug":"amitriptyline","company":"Astrazeneca"},{"name":"amoxapine","slug":"amoxapine","company":"Lederle"},{"name":"bupropion","slug":"bupropion","company":"Glaxosmithkline"},{"name":"citalopram","slug":"citalopram","company":"Forest Labs"}],"globalPrevalence":280000000}],"mechanism":{"modality":"Small Molecule","drugClass":"caroxazone","explanation":"In simple terms, Timostenil is believed to help regulate the balance of chemicals in the brain that affect mood, such as serotonin and dopamine. This can help alleviate symptoms of depression, but the exact way it does this is not yet fully understood.","oneSentence":"Timostenil is thought to work by modulating neurotransmitter activity in the brain.","technicalDetail":"As a caroxazone, Timostenil is a type of small molecule that interacts with specific receptors in the brain, potentially influencing the activity of neurotransmitters like serotonin and dopamine, which play a crucial role in mood regulation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3704","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CAROXAZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:15:24.125958","biosimilars":[],"competitors":[],"genericName":"caroxazone","indications":{"approved":[{"name":"Depressive disorder","source":"DrugCentral","snomedId":35489007,"regulator":"FDA","usPrevalence":21000000,"globalPrevalence":280000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"807N226MNL","CHEBI":"CHEBI:134867","INN_ID":"3354","UMLSCUI":"C0054820","ChEMBL_ID":"CHEMBL2104164","KEGG_DRUG":"D03409","DRUGBANK_ID":"DB09254","PUBCHEM_CID":"29083","MESH_SUPPLEMENTAL_RECORD_UI":"C006919"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":13,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1989","pmid":"2790290","title":"Effects of phenylethylamine on rat locomotor behavior and avoidance learning.","journal":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"date":"1986 Sep","pmid":"3756328","title":"[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].","journal":"Biulleten' eksperimental'noi biologii i meditsiny"},{"date":"1982 Jul-Aug","pmid":"6889985","title":"[Comparative pharmacological study of the antidepressants pyrazidol, inkazan, caroxazone and imipramine].","journal":"Farmakologiia i toksikologiia"},{"date":"1982","pmid":"7046361","title":"Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials.","journal":"Advances in biochemical psychopharmacology"},{"date":"1981 Oct 1","pmid":"6170295","title":"Studies on the mechanism of action of caroxazone, a new antidepressant drug.","journal":"Biochemical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Timostenil is a small molecule modality. It is also known by the synonyms CAROXAZONA, CAROXAZONE, CAROXAZONE, F.I. 6654, and FI-6654.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}