{"id":"carfecillin","rwe":[],"tags":[{"label":"Penicillin-class Antibacterial","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G01AA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Urinary","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"carbenicillin phenyl","offLabel":[],"synonyms":["carfecillin sodium","BRL-3475","carfecillin","carbenicillin phenyl","carbenicillin phenyl ester"],"timeline":[],"brandName":"Carbenicillin Phenyl","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Penicillin-class Antibacterial","explanation":"Imagine your body's cells are like buildings, and bacteria are like construction workers. Carfecillin is like a tool that prevents the construction workers from building new walls, causing their 'building' to collapse and die. This is because carfecillin interferes with the bacteria's ability to produce a key component of their cell walls.","oneSentence":"Carfecillin works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Carfecillin exerts its antibacterial effect by binding to and inhibiting the enzyme transpeptidase, which is essential for the cross-linking of peptidoglycan in bacterial cell walls, ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/507","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=carfecillin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:14:56.796872","biosimilars":[],"competitors":[{"drugName":"nystatin","drugSlug":"nystatin","fdaApproval":"1964-07-08","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"natamycin","drugSlug":"natamycin","fdaApproval":"1978-10-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"amphotericin B","drugSlug":"amphotericin-b","fdaApproval":"1964-11-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"candicidin","drugSlug":"candicidin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"chloramphenicol","drugSlug":"chloramphenicol","fdaApproval":"1950-12-08","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clindamycin","drugSlug":"clindamycin","fdaApproval":"1970-02-22","patentExpiry":"Sep 22, 2036","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"carfecillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nystatin","brandName":"nystatin","genericName":"nystatin","approvalYear":"1964","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin B","approvalYear":"1964","relationship":"same-class"},{"drugId":"candicidin","brandName":"candicidin","genericName":"candicidin","approvalYear":"","relationship":"same-class"},{"drugId":"chloramphenicol","brandName":"chloramphenicol","genericName":"chloramphenicol","approvalYear":"1950","relationship":"same-class"},{"drugId":"oxytetracycline","brandName":"oxytetracycline","genericName":"oxytetracycline","approvalYear":"1964","relationship":"same-class"},{"drugId":"clindamycin","brandName":"clindamycin","genericName":"clindamycin","approvalYear":"1970","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"d00092","NDDF":"002700","UNII":"9UU4XDB74X","CHEBI":"CHEBI:3414","VANDF":"4019654","INN_ID":"3487","RXNORM":"2015","UMLSCUI":"C0007241","ChEMBL_ID":"CHEMBL1095283","KEGG_DRUG":"D02199","DRUGBANK_ID":"DB13506","PDB_CHEM_ID":" 0JM","PUBCHEM_CID":"33672","SNOMEDCT_US":"323761001","IUPHAR_LIGAND_ID":"12288","MESH_DESCRIPTOR_UI":"D002323"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":29,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"G01AA08","allCodes":["G01AA08"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Carbenicillin Phenyl, also known as carfecillin, is a Penicillin-class Antibacterial small molecule. It is a derivative of carbenicillin, but its original developer and current owner are unknown. The exact target of carfecillin is not specified, and its commercial status, including FDA approval and off-patent status, is also unclear. Carfecillin is used to treat bacterial infections, but its approved indications are not provided. As a result, its half-life, bioavailability, and generic manufacturers are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}