{"id":"cardio-selective-beta-blocker-group","safety":{"commonSideEffects":[{"rate":"null","effect":"Bradycardia"},{"rate":"null","effect":"Fatigue"},{"rate":"null","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1402326","moleculeType":"Small molecule","molecularWeight":"540.13"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Cardio-selective beta blockers, like this drug, primarily target beta-1 receptors in the heart, reducing heart rate and blood pressure without significantly affecting beta-2 receptors in the lungs. This leads to a decrease in myocardial oxygen demand and a reduction in the risk of cardiovascular events.","oneSentence":"Blocks beta-1 adrenergic receptors to reduce heart rate and blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:59.167Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT04704947","phase":"PHASE3","title":"Clinical Study Evaluating Beta Blockers Use and Fracture Risk in Patients With Primary Osteoporosis","status":"RECRUITING","sponsor":"Sherief Abd-Elsalam","startDate":"2017-10-01","conditions":"Beta Blocker Toxicity","enrollment":50},{"nctId":"NCT01587638","phase":"","title":"Use of Beta-blockers and Risk of New Onset Diabetes","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-04","conditions":"Hypertension","enrollment":12336}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["concor"],"phase":"phase_3","status":"active","brandName":"cardio-selective beta blocker group","genericName":"cardio-selective beta blocker group","companyName":"Sherief Abd-Elsalam","companyId":"sherief-abd-elsalam","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cardio-selective beta blockers are a group of medications used to treat conditions such as hypertension and beta blocker toxicity. They are also being studied in relation to fracture risk in patients with primary osteoporosis, alongside nonselective beta blockers and alendronate sodium.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}