{"id":"carbromal","rwe":[{"pmid":"11307856","year":"2001","title":"Regional potassium distribution in the brain in forensic relevant types of intoxication preliminary morphometric evaluation using a histochemical method.","finding":"","journal":"Neurotoxicology","studyType":"Clinical Study"},{"pmid":"1486827","year":"1992","title":"[Periodic discharges of sleep spindles with placebo and zopiclone].","finding":"","journal":"EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete","studyType":"Clinical Study"},{"pmid":"1363691","year":"1992","title":"Determination of meprobamate in pharmaceutical dosage forms also containing carbromal by liquid chromatography and indirect photometric detection.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"2079506","year":"1990","title":"Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"},{"pmid":"3086068","year":"1986","title":"[Primary polyuric kidney failure and acute yellow liver dystrophy following infusion of glucose substitutes in children].","finding":"","journal":"Deutsche medizinische Wochenschrift (1946)","studyType":"Clinical Study"}],"tags":[{"label":"carbromal","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05CM04","category":"atc"},{"label":"Active","category":"status"},{"label":"Insomnia","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bromadal","offLabel":[],"synonyms":["carbromal","bromacetocarbamide","bromadal","bromdiethylacetylurea","bromodiethylacetylcarbamide"],"timeline":[],"brandName":"Bromadal","ecosystem":[{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000}],"mechanism":{"modality":"Small Molecule","drugClass":"carbromal","explanation":"Imagine your brain has a 'volume control' for different signals. Bromadal helps turn down the volume on signals that keep you awake and alert, making it easier to fall asleep. This is achieved by influencing the activity of neurotransmitters like GABA, which is a key player in regulating sleep and relaxation.","oneSentence":"Bromadal works by enhancing the activity of neurotransmitters in the brain that promote relaxation and sleep.","technicalDetail":"Bromadal is a carbamate derivative that acts as a GABA receptor agonist, enhancing the inhibitory effects of GABA on neuronal activity, leading to sedative and hypnotic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/504","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CARBROMAL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:10:28.104015","biosimilars":[],"competitors":[{"drugName":"scopolamine","drugSlug":"scopolamine","fdaApproval":"1979-12-31","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"propiomazine","drugSlug":"propiomazine","fdaApproval":"1960-12-05","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"triclofos","drugSlug":"triclofos","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"ethchlorvynol","drugSlug":"ethchlorvynol","fdaApproval":"1961-05-10","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dexmedetomidine","drugSlug":"dexmedetomidine","fdaApproval":"1999-12-17","patentExpiry":"Jun 26, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"suvorexant","drugSlug":"suvorexant","fdaApproval":"2014-08-13","patentExpiry":"Nov 20, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lemborexant","drugSlug":"lemborexant","fdaApproval":"2019-12-20","patentExpiry":"Sep 20, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"carbromal","indications":{"approved":[{"name":"Insomnia","source":"DrugCentral","snomedId":193462001,"regulator":"FDA","usPrevalence":70000000,"globalPrevalence":750000000,"prevalenceMethod":"curated","prevalenceSource":"Sleep Medicine Reviews, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"scopolamine","brandName":"scopolamine","genericName":"scopolamine","approvalYear":"1979","relationship":"same-class"},{"drugId":"propiomazine","brandName":"propiomazine","genericName":"propiomazine","approvalYear":"1960","relationship":"same-class"},{"drugId":"triclofos","brandName":"triclofos","genericName":"triclofos","approvalYear":"","relationship":"same-class"},{"drugId":"ethchlorvynol","brandName":"ethchlorvynol","genericName":"ethchlorvynol","approvalYear":"1961","relationship":"same-class"},{"drugId":"dexmedetomidine","brandName":"dexmedetomidine","genericName":"dexmedetomidine","approvalYear":"1999","relationship":"same-class"},{"drugId":"suvorexant","brandName":"suvorexant","genericName":"suvorexant","approvalYear":"2014","relationship":"same-class"},{"drugId":"lemborexant","brandName":"lemborexant","genericName":"lemborexant","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001437","UNII":"0Y299JY9V3","CHEBI":"CHEBI:134961","INN_ID":"53","RXNORM":"2067","UMLSCUI":"C0007077","ChEMBL_ID":"CHEMBL1697828","KEGG_DRUG":"D02619","DRUGBANK_ID":"DB13817","PUBCHEM_CID":"6488","SNOMEDCT_US":"56325002","MESH_SUPPLEMENTAL_RECORD_UI":"C084812"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":108,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05CM04","allCodes":["N05CM04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2001 Feb","pmid":"11307856","title":"Regional potassium distribution in the brain in forensic relevant types of intoxication preliminary morphometric evaluation using a histochemical method.","journal":"Neurotoxicology"},{"date":"1992 Dec","pmid":"1486827","title":"[Periodic discharges of sleep spindles with placebo and zopiclone].","journal":"EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete"},{"date":"1992 Oct-Dec","pmid":"1363691","title":"Determination of meprobamate in pharmaceutical dosage forms also containing carbromal by liquid chromatography and indirect photometric detection.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1990 Sep 14","pmid":"2079506","title":"Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry.","journal":"Journal of chromatography"},{"date":"1986 Jun 20","pmid":"3086068","title":"[Primary polyuric kidney failure and acute yellow liver dystrophy following infusion of glucose substitutes in children].","journal":"Deutsche medizinische Wochenschrift (1946)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bromadal, also known as CARBROMAL, is a small molecule drug in the carbromal class. It is used to treat insomnia, a common sleep disorder. The commercial status of Bromadal is currently unknown, and it may be patented or available as a generic medication. Key safety considerations for Bromadal are not well-documented, but it is essential to follow the recommended dosage and consult a healthcare professional for guidance. Further research is needed to fully understand the pharmacological properties of Bromadal.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}