{"id":"carboxymethylcellulose-based-lubricant-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Eye irritation or stinging"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carboxymethylcellulose (CMC) is a cellulose derivative that forms a protective film over the cornea and conjunctiva. By increasing tear film viscosity and stability, it reduces evaporation and provides prolonged lubrication and comfort. This mechanical action addresses symptoms of dry eye disease without targeting specific molecular pathways.","oneSentence":"Carboxymethylcellulose acts as a viscous lubricant that coats and protects the ocular surface, mimicking natural tears to relieve dryness and irritation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:12.710Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / keratoconjunctivitis sicca"},{"name":"Ocular surface irritation and discomfort"}]},"trialDetails":[{"nctId":"NCT06913387","phase":"NA","title":"Comparative Efficacy of Lipid Based Artificial Tears vs Aqueous Based Artificial Tears in Managing EDE","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2025-03-20","conditions":"Evaporative Dry Eye","enrollment":60},{"nctId":"NCT03380624","phase":"PHASE4","title":"Tear Lipid Layer Thickness With Emollient Eye Drops","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2017-03-01","conditions":"Dry Eye Syndromes","enrollment":21},{"nctId":"NCT02121847","phase":"PHASE4","title":"Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-04-03","conditions":"Dry Eye Syndromes","enrollment":40},{"nctId":"NCT01459588","phase":"PHASE3","title":"Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease","status":"COMPLETED","sponsor":"Allergan","startDate":"2011-10-01","conditions":"Dry Eye Syndromes","enrollment":315},{"nctId":"NCT02007174","phase":"","title":"Bevacizumab Injection for Recurrent Pterygium","status":"COMPLETED","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2012-03","conditions":"Recurrent Pterygium","enrollment":38},{"nctId":"NCT02455050","phase":"PHASE3","title":"A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-12","conditions":"Dry Eye Syndromes","enrollment":79},{"nctId":"NCT01664949","phase":"PHASE3","title":"A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye Disease","status":"COMPLETED","sponsor":"Allergan","startDate":"2013-01","conditions":"Dry Eye Disease","enrollment":460},{"nctId":"NCT00932477","phase":"NA","title":"Safety and Tolerability of Artificial Tears in Dry Eye Subjects","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-08","conditions":"Dry Eye Syndrome","enrollment":47},{"nctId":"NCT01010282","phase":"NA","title":"Safety and Efficacy of Two Artificial Tears in Dry Eye Subjects","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-11","conditions":"Dry Eye Syndrome","enrollment":288},{"nctId":"NCT00544713","phase":"NA","title":"Evaluate the Safety and Efficacy of a New Artificial Tear for Use After LASIK Surgery","status":"COMPLETED","sponsor":"Allergan","startDate":"2007-09","conditions":"Dry Eye Syndrome","enrollment":228},{"nctId":"NCT00514852","phase":"NA","title":"Safety and Efficacy of an Artificial Tear for the Treatment of Dry Eye","status":"COMPLETED","sponsor":"Allergan","startDate":"2007-10","conditions":"Dry Eye Syndrome","enrollment":316}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Refresh OPTIVE® Advanced"],"phase":"marketed","status":"active","brandName":"carboxymethylcellulose-based lubricant eye drops","genericName":"carboxymethylcellulose-based lubricant eye drops","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carboxymethylcellulose acts as a viscous lubricant that coats and protects the ocular surface, mimicking natural tears to relieve dryness and irritation. Used for Dry eye disease / keratoconjunctivitis sicca, Ocular surface irritation and discomfort.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}