{"id":"carboxymethylcellulose-0-5-glycerin-0-9","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL2109000","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carboxymethylcellulose is a cellulose derivative that acts as a lubricant and demulcent, coating the cornea and conjunctiva to reduce friction and protect the ocular surface. Glycerin is a humectant that draws moisture to the eye and helps retain hydration on the tear film. Together, these agents mimic natural tears and provide sustained lubrication for symptomatic dry eye relief.","oneSentence":"Carboxymethylcellulose and glycerin work together to lubricate and hydrate the ocular surface, providing relief from dry eye symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:08.743Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye syndrome / keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT06375343","phase":"PHASE1","title":"Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive®","status":"NOT_YET_RECRUITING","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2026-01-30","conditions":"Dry Eye Disease, Dry Eye Sensation, Ocular Surface Disease","enrollment":32},{"nctId":"NCT02117687","phase":"PHASE4","title":"A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-05-14","conditions":"Dry Eye Syndromes, Keratoconjunctivitis Sicca","enrollment":80},{"nctId":"NCT00938704","phase":"PHASE4","title":"Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-06","conditions":"Dry Eye Syndromes","enrollment":71},{"nctId":"NCT00987727","phase":"PHASE4","title":"Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-11","conditions":"Dry Eye Syndromes, Keratoconjunctivitis Sicca","enrollment":82}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Optive™ Sensitive"],"phase":"marketed","status":"active","brandName":"carboxymethylcellulose 0.5% +glycerin 0.9%","genericName":"carboxymethylcellulose 0.5% +glycerin 0.9%","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carboxymethylcellulose and glycerin work together to lubricate and hydrate the ocular surface, providing relief from dry eye symptoms. Used for Dry eye syndrome / keratoconjunctivitis sicca.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}