{"id":"carbon-tetrachloride","rwe":[{"pmid":"41901341","year":"2026","title":"From a Multi-Omics Signature to a Therapeutic Candidate: Computational Prediction and Experimental Validation in Liver Fibrosis.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41899461","year":"2026","title":"Multi-Strain Probiotic and Bee Pollen Supplementation Attenuates CCl(4)-Induced Altered Intestinal Tight Junctions in Rodents.","finding":"","journal":"Current issues in molecular biology","studyType":"Clinical Study"},{"pmid":"41891662","year":"2026","title":"Fluorescent Tri(biphenyl-4-yl)Amine-Derived Molecule for Sensing of Chloromethanes, and Picric Acid, Breaking of J-Type Aggregates and White Light-Emitting Diode Investigations.","finding":"","journal":"Chemistry, an Asian journal","studyType":"Clinical Study"},{"pmid":"41873577","year":"2026","title":"Route-Dependent Proteomic Landscape in Mouse Models of Carbon Tetrachloride-Induced Hepatic Fibrosis.","finding":"","journal":"Journal of proteome research","studyType":"Clinical Study"},{"pmid":"41865375","year":"2026","title":"IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury.","finding":"","journal":"Cell reports","studyType":"Clinical Study"}],"tags":[{"label":"carbon tetrachloride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Cytochrome P450 2E1","category":"target"},{"label":"CYP2E1","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tetrafinol","offLabel":[],"synonyms":["carbon tetrachloride","benzinoform","perchloromethane","tetrachloromethane","tetrafinol"],"timeline":[],"brandName":"Tetrafinol","ecosystem":[],"mechanism":{"target":"Cytochrome P450 2E1","targets":[{"gene":"CYP2E1","source":"DrugCentral","target":"Cytochrome P450 2E1","protein":"Cytochrome P450 2E1"}],"modality":"Small Molecule","drugClass":"carbon tetrachloride","explanation":"Imagine your body has a factory that breaks down toxic substances. Cytochrome P450 2E1 is a key worker in this factory. Carbon tetrachloride is like a tool that can temporarily stop this worker from doing its job, which may help reduce the damage caused by toxic substances.","oneSentence":"Carbon tetrachloride works by binding to the Cytochrome P450 2E1 enzyme, potentially inhibiting its activity.","technicalDetail":"Carbon tetrachloride (CCl4) is a potent inhibitor of the Cytochrome P450 2E1 enzyme, which is involved in the metabolism of various substrates, including ethanol and acetaminophen. By binding to the enzyme, CCl4 may reduce its activity and alter the metabolism of these substrates, potentially leading to changes in their toxicity profiles."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3067","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=carbon%20tetrachloride","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=carbon tetrachloride","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:10:24.510093","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"carbon tetrachloride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07333313","phase":"NA","title":"Study of Oral Uremic Toxin Absorbent/Probiotics to Modulate Systemic Inflammation and Retard the Progression of Chronic Kidney Disease in Patients With Diabetes.","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2024-12-31","conditions":["Oral Uremic Toxin Absorbent"],"enrollment":300,"completionDate":"2029-12-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"NOCODE","NDDF":"009950","UNII":"CL2T97X0V0","CHEBI":"CHEBI:27385","RXNORM":"2383337","UMLSCUI":"C0007022","ChEMBL_ID":"CHEMBL44814","PUBCHEM_CID":"5943","MESH_DESCRIPTOR_UI":"D002251"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":13014,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 17","pmid":"41901341","title":"From a Multi-Omics Signature to a Therapeutic Candidate: Computational Prediction and Experimental Validation in Liver Fibrosis.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2026 Mar 13","pmid":"41899461","title":"Multi-Strain Probiotic and Bee Pollen Supplementation Attenuates CCl(4)-Induced Altered Intestinal Tight Junctions in Rodents.","journal":"Current issues in molecular biology"},{"date":"2026 Mar","pmid":"41891662","title":"Fluorescent Tri(biphenyl-4-yl)Amine-Derived Molecule for Sensing of Chloromethanes, and Picric Acid, Breaking of J-Type Aggregates and White Light-Emitting Diode Investigations.","journal":"Chemistry, an Asian journal"},{"date":"2026 Mar 24","pmid":"41873577","title":"Route-Dependent Proteomic Landscape in Mouse Models of Carbon Tetrachloride-Induced Hepatic Fibrosis.","journal":"Journal of proteome research"},{"date":"2026 Mar 20","pmid":"41865375","title":"IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury.","journal":"Cell reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Tetrafinol, also known as carbon tetrachloride, is a small molecule that targets the Cytochrome P450 2E1 enzyme. However, there is limited information available on this compound, suggesting it may not be a commercially available or FDA-approved medication. As a result, its commercial status, approved indications, and pharmacokinetic properties are unknown. Further research is needed to understand its potential therapeutic applications and safety profile. Unfortunately, this information is not available in the provided facts.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}