{"id":"carbomer-980","safety":{"commonSideEffects":["Mild skin irritation","Eye irritation (ophthalmic use)","Allergic contact dermatitis (rare)"],"contraindications":["Known hypersensitivity to carbomer or acrylic acid polymers"]},"_chembl":{"chemblId":"CHEMBL5836232","moleculeType":null,"molecularWeight":"505.47"},"modality":"Small molecule","_dailymed":null,"mechanism":{"explanation":"Carbomer 980 is not a pharmacologically active compound. It functions as a pharmaceutical excipient that cross-links when neutralized, creating a gel matrix that can suspend active ingredients, control drug release rates, and improve product stability and patient acceptability.","oneSentence":"Carbomer 980 acts as an inert polymer that swells in water to form viscous gels, providing structural support and controlled release properties in pharmaceutical formulations."},"_scrapedAt":"2026-03-28T05:56:09.449Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123248,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Hydroxypropyl methylcellulose","brand":null,"company":null,"rationale":"Alternative pharmaceutical thickening agent and gel-forming excipient"},{"name":"Carbomer 940","brand":null,"company":null,"rationale":"Related carbomer polymer with similar excipient applications"},{"name":"Sodium carboxymethylcellulose","brand":null,"company":null,"rationale":"Competing cellulose-based viscosity modifier for topical products"}],"description":"Carbomer 980 is a high molecular weight polymer of acrylic acid used primarily as a pharmaceutical excipient and thickening agent in topical formulations. It functions as a rheology modifier and emulsion stabilizer in gels, creams, and ophthalmic preparations rather than as an active pharmaceutical ingredient.","indications":{"approved":[{"status":"approved","condition":"Pharmaceutical excipient for topical formulations","patientPopulation":"All populations as formulation component"}]},"trialDetails":[{"nctId":"NCT06190028","phase":"NA","title":"Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy","status":"TERMINATED","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2023-06-14","conditions":"Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome, Ocular Hypertension and Concomitant Dry Eye Syndrome","enrollment":65},{"nctId":"NCT03997851","phase":"PHASE1, PHASE2","title":"Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects","status":"COMPLETED","sponsor":"University of Miami","startDate":"2019-07-22","conditions":"Pruritus","enrollment":17},{"nctId":"NCT03005067","phase":"PHASE2","title":"To Evaluate the Efficacy and Safety of 1146A Nasal Spray in Adult Participants With Symptoms of Common Cold","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-12-29","conditions":"Common Cold","enrollment":171},{"nctId":"NCT02832362","phase":"PHASE1","title":"Local Nasal Tolerability and Safety Study of 1146A in Healthy Adult Participants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-06-11","conditions":"Common Cold","enrollment":30}],"_emaApprovals":[],"_faersSignals":[{"count":16,"reaction":"RASH"},{"count":10,"reaction":"LIP SWELLING"},{"count":9,"reaction":"NAUSEA"},{"count":8,"reaction":"DIZZINESS"},{"count":8,"reaction":"SWELLING FACE"},{"count":8,"reaction":"VOMITING"},{"count":7,"reaction":"ABDOMINAL PAIN"},{"count":6,"reaction":"BURNING SENSATION"},{"count":6,"reaction":"DIARRHOEA"},{"count":6,"reaction":"HYPONATRAEMIA"}],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Topical vehicle gel"],"phase":"phase_1","status":"active","brandName":"Carbomer 980","genericName":"Carbomer 980","companyName":"GlaxoSmithKline","companyId":"gsk","firstApprovalDate":"","aiSummary":"Carbomer 980 is a substance that has been studied in clinical trials for various conditions, including the common cold, dry eye syndrome, glaucoma, and ocular hypertension. It has been tested as a treatment in nasal and ocular applications, with studies evaluating its local tolerability and safety in healthy adult participants.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}