{"id":"carbocysteine-lysine","rwe":[{"pmid":"31378916","year":"2019","title":"A prospective study of the effects of carbocysteine lysine salt on frequency of exacerbations in COPD patients treated with or without inhaled steroids.","finding":"","journal":"European review for medical and pharmacological sciences","studyType":"Clinical Study"},{"pmid":"25734311","year":"2014","title":"[The possibilities for the treatment of exudative otitis media in the children presenting with chronic adenoiditis].","finding":"","journal":"Vestnik otorinolaringologii","studyType":"Clinical Study"},{"pmid":"22963552","year":"2013","title":"Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.","finding":"","journal":"Current medicinal chemistry","studyType":"Clinical Study"},{"pmid":"19088427","year":"2008","title":"S-CMC-Lys protective effects on human respiratory cells during oxidative stress.","finding":"","journal":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","studyType":"Clinical Study"},{"pmid":"18046899","year":"2006","title":"Antioxidant therapies in COPD.","finding":"","journal":"International journal of chronic obstructive pulmonary disease","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"carbocysteine lysine","offLabel":[],"synonyms":["carbocysteine lysine","carbocysteine-lysine","SCMC-Lys"],"timeline":[],"brandName":"Carbocysteine Lysine","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your airways are clogged with thick, sticky mucus. Carbocysteine Lysine helps break down this mucus, making it thinner and easier to cough up. This can help relieve symptoms of respiratory conditions such as bronchiectasis.","oneSentence":"Carbocysteine Lysine is thought to work by modifying the properties of mucus in the respiratory tract, making it easier to expel.","technicalDetail":"Carbocysteine Lysine is believed to exert its effects by increasing the concentration of reduced glutathione in the respiratory tract, which in turn reduces the viscosity of mucus and facilitates its clearance."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3892","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=carbocysteine-lysine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=carbocysteine-lysine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:10:20.824133","biosimilars":[],"competitors":[],"genericName":"carbocysteine-lysine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02858193","phase":"PHASE1","title":"Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2016-07-04","conditions":["Bronchitis"],"enrollment":30,"completionDate":"2016-10-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"10705","NDDF":"000931","UNII":"1D1Y95PXXA","CHEBI":"CHEBI:135304","VANDF":"4018682","INN_ID":"6166","RXNORM":"1427149","UMLSCUI":"C0054690","DRUGBANK_ID":"DB00123","PDB_CHEM_ID":" LYS","PUBCHEM_CID":"6452154","SNOMEDCT_US":"418834008","SECONDARY_CAS_RN":"49673-81-6","MESH_DESCRIPTOR_UI":"D008239","MESH_SUPPLEMENTAL_RECORD_UI":"C034932"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Respiratory"],"biosimilarFilings":[],"recentPublications":[{"date":"2019 Aug","pmid":"31378916","title":"A prospective study of the effects of carbocysteine lysine salt on frequency of exacerbations in COPD patients treated with or without inhaled steroids.","journal":"European review for medical and pharmacological sciences"},{"date":"2014","pmid":"25734311","title":"[The possibilities for the treatment of exudative otitis media in the children presenting with chronic adenoiditis].","journal":"Vestnik otorinolaringologii"},{"date":"2013","pmid":"22963552","title":"Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.","journal":"Current medicinal chemistry"},{"date":"2008","pmid":"19088427","title":"S-CMC-Lys protective effects on human respiratory cells during oxidative stress.","journal":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"date":"2006","pmid":"18046899","title":"Antioxidant therapies in COPD.","journal":"International journal of chronic obstructive pulmonary disease"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Carbocysteine Lysine is a small molecule with an unknown mechanism of action. It is being studied as a treatment for bronchitis, with clinical trials comparing its bioequivalence to a syrup formulation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}