{"id":"carbasalate-calcium","rwe":[],"tags":[{"label":"carbasalate calcium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AC08","category":"atc"},{"label":"Active","category":"status"},{"label":"UMC Utrecht","category":"company"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":72.727,"date":"","count":9,"signal":"SARS-CoV-2 sepsis","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=73)"},{"llr":62.034,"date":"","count":9,"signal":"Herpes zoster reactivation","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=62)"},{"llr":56.957,"date":"","count":9,"signal":"Scrotal pain","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=57)"},{"llr":51.049,"date":"","count":9,"signal":"Hypothalamo-pituitary disorder","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=51)"}],"commonSideEffects":[{"effect":"SARS-CoV-2 sepsis","drugRate":"LLR 73","severity":"common"},{"effect":"Herpes zoster reactivation","drugRate":"LLR 62","severity":"common"},{"effect":"Scrotal pain","drugRate":"LLR 57","severity":"common"},{"effect":"Hypothalamo-pituitary disorder","drugRate":"LLR 51","severity":"common"}]},"trials":[],"aliases":[],"company":"UMC Utrecht","patents":[],"pricing":[],"allNames":"calpirinsan","offLabel":[],"synonyms":["carbasalate calcium","calcium carbasalate","calcium carbaspirin","calpirinsan","carbaspirin calcium"],"timeline":[],"brandName":"Calpirinsan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"carbasalate calcium","explanation":"Think of calcium ions like keys that unlock many bodily functions, such as muscle contractions and nerve impulses. Calpirinsan acts like a 'key catcher' that binds to these calcium ions, potentially altering their activity. This can have various effects on the body, but the exact nature of these effects is still unknown.","oneSentence":"Calpirinsan works by binding to calcium ions, which are essential for various bodily functions.","technicalDetail":"Calpirinsan is a calcium chelator that binds to calcium ions through its carboxylate groups, forming a stable complex that can alter calcium-dependent processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4387","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Carbasalate%20calcium","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Carbasalate calcium","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:11:00.630884","biosimilars":[],"competitors":[{"drugName":"clopidogrel","drugSlug":"clopidogrel","fdaApproval":"1997-11-17","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticlopidine","drugSlug":"ticlopidine","fdaApproval":"1991-10-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-class"},{"drugName":"dipyridamole","drugSlug":"dipyridamole","fdaApproval":"1961-12-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"epoprostenol","drugSlug":"epoprostenol","fdaApproval":"1995-09-20","patentExpiry":"Mar 15, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"iloprost","drugSlug":"iloprost","fdaApproval":"2004-12-29","patentExpiry":"Jul 18, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"abciximab","drugSlug":"abciximab","fdaApproval":"1993-12-16","relationship":"same-class"},{"drugName":"eptifibatide","drugSlug":"eptifibatide","fdaApproval":"1998-05-18","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tirofiban","drugSlug":"tirofiban","fdaApproval":"1998-05-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"treprostinil","drugSlug":"treprostinil","fdaApproval":"2002-05-21","patentExpiry":"Sep 5, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prasugrel","drugSlug":"prasugrel","fdaApproval":"2009-07-10","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cilostazol","drugSlug":"cilostazol","fdaApproval":"1999-01-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticagrelor","drugSlug":"ticagrelor","fdaApproval":"2011-07-20","patentExpiry":"Oct 17, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cangrelor","drugSlug":"cangrelor","fdaApproval":"2015-06-22","patentExpiry":"Nov 10, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"vorapaxar","drugSlug":"vorapaxar","fdaApproval":"2014-05-08","patentExpiry":"Dec 23, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"selexipag","drugSlug":"selexipag","fdaApproval":"2015-12-21","patentExpiry":"Oct 31, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"carbasalate calcium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clopidogrel","brandName":"clopidogrel","genericName":"clopidogrel","approvalYear":"1997","relationship":"same-class"},{"drugId":"ticlopidine","brandName":"ticlopidine","genericName":"ticlopidine","approvalYear":"1991","relationship":"same-class"},{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-class"},{"drugId":"dipyridamole","brandName":"dipyridamole","genericName":"dipyridamole","approvalYear":"1961","relationship":"same-class"},{"drugId":"epoprostenol","brandName":"epoprostenol","genericName":"epoprostenol","approvalYear":"1995","relationship":"same-class"},{"drugId":"iloprost","brandName":"iloprost","genericName":"iloprost","approvalYear":"2004","relationship":"same-class"},{"drugId":"abciximab","brandName":"abciximab","genericName":"abciximab","approvalYear":"1993","relationship":"same-class"},{"drugId":"eptifibatide","brandName":"eptifibatide","genericName":"eptifibatide","approvalYear":"1998","relationship":"same-class"},{"drugId":"tirofiban","brandName":"tirofiban","genericName":"tirofiban","approvalYear":"1998","relationship":"same-class"},{"drugId":"treprostinil","brandName":"treprostinil","genericName":"treprostinil","approvalYear":"2002","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07486570","phase":"NA","title":"Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery","status":"RECRUITING","sponsor":"Medisch Spectrum Twente","startDate":"2026-02-01","conditions":["Mesenteric Vascular Disease","Colorectal Surgery","Preventive Intervention"],"enrollment":360,"completionDate":"2029-01-01"},{"nctId":"NCT02565693","phase":"PHASE2","title":"Apixaban After Anticoagulation-associated Intracerebral Haemorrhage in Patients With Atrial Fibrillation","status":"COMPLETED","sponsor":"UMC Utrecht","startDate":"2014-09","conditions":["Cerebral Hemorrhage","Atrial Fibrillation"],"enrollment":101,"completionDate":"2021-01-31"},{"nctId":"NCT01379079","phase":"PHASE4","title":"Aspirin in Reduction of Tension II Study","status":"COMPLETED","sponsor":"Leiden University Medical Center","startDate":"2011-04","conditions":["Hypertension","Cardiovascular Diseases"],"enrollment":290,"completionDate":"2013-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001595","UNII":"N667F17JP1","INN_ID":"1656","UMLSCUI":"C0054547","ChEMBL_ID":"CHEMBL3833325","KEGG_DRUG":"D03385","DRUGBANK_ID":"DB13612","PUBCHEM_CID":"21975","SNOMEDCT_US":"111122008","MESH_SUPPLEMENTAL_RECORD_UI":"C002942"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"UMC Utrecht","relationship":"Current Owner"}],"publicationCount":14,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AC08","allCodes":["B01AC08","N02BA15"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"UMC Utrecht","companyId":"umc-utrecht","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calpirinsan, also known as carbasalate calcium, is a small molecule drug of the carbasalate calcium class. Its exact target and mechanism of action are unknown, but it is believed to work by binding to calcium ions. Calpirinsan is not FDA-approved for any indications, and its commercial status, including patent status and generic availability, is unclear. Further research is needed to determine its safety and efficacy. As a result, key safety considerations and approved indications are currently unavailable.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}