{"id":"carbamazepine-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Ataxia"},{"rate":null,"effect":"Diplopia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash / Stevens-Johnson syndrome"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Agranulocytosis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carbamazepine works primarily by inhibiting voltage-gated sodium channels, which decreases the influx of sodium ions into neurons and stabilizes the neuronal membrane. This reduces the frequency of action potentials and prevents the spread of abnormal electrical activity characteristic of seizures. The implant formulation provides sustained local or systemic drug delivery to maintain therapeutic levels.","oneSentence":"Carbamazepine is an anticonvulsant that stabilizes neuronal membranes by blocking sodium channels, reducing repetitive neuronal firing and propagation of seizure activity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:29:47.089Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epilepsy / seizure disorders"},{"name":"Trigeminal neuralgia"},{"name":"Bipolar disorder"}]},"trialDetails":[{"nctId":"NCT07413731","phase":"","title":"Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation","status":"RECRUITING","sponsor":"Brai²n","startDate":"2025-02-03","conditions":"Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation","enrollment":50},{"nctId":"NCT03307863","phase":"PHASE4","title":"Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy","status":"SUSPENDED","sponsor":"University of Sao Paulo","startDate":"2017-11-01","conditions":"Contraception, Drug Interactions","enrollment":69}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Carbamazepine-Implant","genericName":"Carbamazepine-Implant","companyName":"University of Sao Paulo","companyId":"university-of-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carbamazepine is an anticonvulsant that stabilizes neuronal membranes by blocking sodium channels, reducing repetitive neuronal firing and propagation of seizure activity. Used for Epilepsy / seizure disorders, Trigeminal neuralgia, Bipolar disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}