{"id":"carbaldrate","rwe":[],"tags":[{"label":"carbaldrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A02AB04","category":"atc"},{"label":"Active","category":"status"},{"label":"Gastric Hypersecretory Conditions","category":"indication"},{"label":"Gastroesophageal reflux disease","category":"indication"},{"label":"Heartburn","category":"indication"},{"label":"Hiatal Hernia with Reflux Esophagitis","category":"indication"},{"label":"Indigestion","category":"indication"},{"label":"Peptic ulcer","category":"indication"}],"phase":"unknown","safety":{"safetySignals":[{"llr":957.999,"date":"","count":183,"signal":"Chronic kidney disease","source":"DrugCentral FAERS","actionTaken":"Reported 183 times (LLR=958)"}],"drugInteractions":[{"url":"/drug/enoxacin","drug":"enoxacin","action":"Monitor closely","effect":"May interact with Dihydroxyaluminum Sodium Carbonate, Enoxacin","source":"DrugCentral","drugSlug":"enoxacin"},{"url":"/drug/lomefloxacin","drug":"lomefloxacin","action":"Monitor closely","effect":"May interact with Dihydroxyaluminum Sodium Carbonate, Lomefloxacin","source":"DrugCentral","drugSlug":"lomefloxacin"}],"commonSideEffects":[{"effect":"Chronic kidney disease","drugRate":"LLR 958","severity":"serious"}],"contraindications":["Aluminum intoxication","Chronic diarrhea","Constipation","Fecal impaction","Gastrointestinal obstruction","Hemorrhoids","Hypophosphatemia","Kidney disease"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["carbaldrate","dihydroxialumini sodium carbonate","dihydroxyaluminum sodium carbonate","aluminum sodium dihydroxide monocarbonate","sodium aluminum carbonate hydroxide","sodium aluminum hydroxycarbonate"],"offLabel":[],"synonyms":["carbaldrate","dihydroxialumini sodium carbonate","dihydroxyaluminum sodium carbonate","aluminum sodium dihydroxide monocarbonate","sodium aluminum carbonate hydroxide","sodium aluminum hydroxycarbonate"],"timeline":[],"ecosystem":[{"indication":"Gastric Hypersecretory Conditions","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"},{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"}],"globalPrevalence":null},{"indication":"Gastroesophageal reflux disease","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"cisapride","slug":"cisapride","company":""}],"globalPrevalence":null},{"indication":"Heartburn","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"}],"globalPrevalence":320000000},{"indication":"Hiatal Hernia with Reflux Esophagitis","otherDrugs":[{"name":"almasilate","slug":"almasilate","company":""},{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"},{"name":"magnesium hydroxide","slug":"magnesium-hydroxide","company":"Mcneil Cons"},{"name":"magnesium silicate","slug":"magnesium-silicate","company":"Sanofi Aventis Us"}],"globalPrevalence":null},{"indication":"Indigestion","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"bismuth subsalicylate","slug":"bismuth-subsalicylate","company":"Prometheus Labs"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Peptic ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":64000000}],"mechanism":{"modality":"Small Molecule","drugClass":"carbaldrate","explanation":"Imagine your stomach is like a cauldron that needs to be carefully controlled. Carbaldrate helps to turn down the heat by reducing the amount of acid produced in the stomach, which can help to alleviate symptoms of heartburn and indigestion.","oneSentence":"Carbaldrate works by reducing stomach acid production.","technicalDetail":"Carbaldrate is believed to exert its effects by inhibiting the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell, thereby reducing gastric acid secretion."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Carbaldrate","title":"Carbaldrate","extract":"Carbaldrate is an antacid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4522","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=carbaldrate","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Carbaldrate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:09:51.898797","biosimilars":[],"competitors":[{"drugName":"algeldrate","drugSlug":"algeldrate","fdaApproval":"1983-12-09","relationship":"same-class"},{"drugName":"aluminium phosphate","drugSlug":"aluminium-phosphate","fdaApproval":"","relationship":"same-class"}],"genericName":"carbaldrate","indications":{"approved":[{"name":"Gastric Hypersecretory Conditions","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Gastroesophageal reflux disease","source":"DrugCentral","snomedId":235595009,"regulator":"FDA"},{"name":"Heartburn","source":"DrugCentral","snomedId":16331000,"regulator":"FDA","usPrevalence":null,"globalPrevalence":320000000,"prevalenceMethod":"curated","prevalenceSource":"BMC Pregnancy Childbirth, 2025 (PMID:41366751)"},{"name":"Hiatal Hernia with Reflux Esophagitis","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Indigestion","source":"DrugCentral","snomedId":162031009,"regulator":"FDA"},{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"}],"offLabel":[{"name":"Multiple endocrine adenomas","source":"DrugCentral","drugName":"carbaldrate","evidenceCount":9064,"evidenceLevel":"strong"},{"name":"Stress-Related GI Mucosal Bleeding Prevention","source":"DrugCentral","drugName":"carbaldrate"},{"name":"Systemic mast cell disease","source":"DrugCentral","drugName":"carbaldrate","evidenceCount":4003,"evidenceLevel":"strong"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"algeldrate","brandName":"algeldrate","genericName":"algeldrate","approvalYear":"1983","relationship":"same-class"},{"drugId":"aluminium-phosphate","brandName":"aluminium phosphate","genericName":"aluminium phosphate","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000148109","MMSL":"4603","NDDF":"001129","UNII":"6931E8LH07","VUID":"4020126","VANDF":"4020126","INN_ID":"5702","RXNORM":"23163","UMLSCUI":"C2827103","ChEMBL_ID":"CHEMBL3707202","KEGG_DRUG":"D03827","DRUGBANK_ID":"DB15825","PUBCHEM_CID":"118984410","SNOMEDCT_US":"3031003","SECONDARY_CAS_RN":"41342-54-5","MESH_SUPPLEMENTAL_RECORD_UI":"C016386"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"A02AB04","allCodes":["A02AB04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"carbaldrate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Carbaldrate is a small molecule drug in the carbaldrate class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat various gastric conditions, including Gastric Hypersecretory Conditions, Gastroesophageal reflux disease, Heartburn, Hiatal Hernia with Reflux Esophagitis, Indigestion, and Peptic ulcer. The commercial status of carbaldrate is unknown, and it is not clear if it is patented or available as a generic medication. Key safety considerations for carbaldrate are not well-documented. Further research is needed to fully understand the pharmacology and safety profile of this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}