{"id":"carac-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Erosion"},{"rate":null,"effect":"Hyperpigmentation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluorouracil is a pyrimidine analog that interferes with nucleotide metabolism and DNA replication in hyperproliferative skin cells. When applied topically as a cream, it selectively targets and destroys abnormal keratinocytes characteristic of actinic keratosis while sparing normal surrounding tissue. The lower concentration formulation (0.5%) in Carac is designed to improve tolerability compared to higher-concentration fluorouracil products.","oneSentence":"Carac Cream is a topical formulation of fluorouracil that inhibits thymidylate synthase to disrupt DNA synthesis in rapidly dividing cells, particularly actinic keratosis lesions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:03.218Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis (solar keratosis)"}]},"trialDetails":[{"nctId":"NCT05413811","phase":"NA","title":"Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2023-03-22","conditions":"Cervical Cancer, CIN2, CIN3","enrollment":180},{"nctId":"NCT07401277","phase":"PHASE1","title":"Actinic Keratoses Treated With 5-fluorouracil Plus 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Used for Actinic keratosis (solar keratosis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}