{"id":"car","safety":{"commonSideEffects":[{"rate":"approximately 10-20%","effect":"Injection site reactions"},{"rate":"approximately 5-10%","effect":"Headache"},{"rate":"approximately 5-10%","effect":"Fatigue"},{"rate":"approximately 5%","effect":"Nausea"},{"rate":"approximately 5%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL106174","moleculeType":"Protein","molecularWeight":"635.76"},"_dailymed":{"setId":"6c1f7cd4-de56-45c1-a734-5e77b4aeb6f7","title":"RYTARY (CARBIDOPA AND LEVODOPA) CAPSULE, EXTENDED RELEASE [AMNEAL PHARMACEUTICALS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cabotegravir is an integrase strand transfer inhibitor (INSTI) that prevents HIV from integrating its genetic material into host cell DNA. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks the enzyme responsible for converting HIV RNA into DNA. Together, these agents provide dual-mechanism suppression of viral replication.","oneSentence":"CAR is a combination antiretroviral therapy containing cabotegravir and rilpivirine that suppresses HIV replication by inhibiting integrase and reverse transcriptase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:54.270Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Central_African_Republic","title":"Central African Republic","extract":"The Central African Republic (CAR) is a landlocked country located in Central Africa. It is bordered by Chad to the north, Sudan to the northeast, South Sudan to the east, the Democratic Republic of the Congo to the south, the Republic of the Congo to the southwest, and Cameroon to the west. The Central African Republic covers a land area of about 620,000 square kilometres (240,000 sq mi). As of 2024, it has a population of 5,357,744, consisting of about 80 ethnic groups. Having been a French colony under the name Ubangi-Shari, French is its official language, with Sango, a Ngbandi-based creole language, as the national and co-official language. Its capital and largest city is Bangui, which is on the southern border with the Democratic Republic of the Congo."},"indications":{"approved":[{"name":"HIV-1 infection in treatment-naive and treatment-experienced adults (as Cabenuva long-acting injectable formulation)"}]},"trialDetails":[{"nctId":"NCT07496073","phase":"PHASE1","title":"A Phase I, Single-arm, Open-label Clinical Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of CHT101 Cell Infusion in Adult Subjects With Recurrent or Progressive Malignant Primary Brain Tumors（CROWN）","status":"NOT_YET_RECRUITING","sponsor":"Tianjin Medical University Cancer Institute and Hospital","startDate":"2026-03-20","conditions":"Brain (Nervous System) Cancers","enrollment":30},{"nctId":"NCT06038474","phase":"PHASE2","title":"Descartes-08 for Patients With Systemic Lupus Erythematosus","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cartesian Therapeutics","startDate":"2024-02-12","conditions":"Systemic Lupus Erythematosus 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