{"id":"captafer","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, vomiting, diarrhea)"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Rash or skin reactions"},{"rate":null,"effect":"Agranulocytosis or neutropenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Captafer works by forming stable complexes with ferric iron (Fe³⁺), facilitating its excretion through urine and feces. This mechanism helps reduce iron accumulation in organs such as the heart, liver, and endocrine glands, preventing iron-related tissue damage and organ dysfunction in patients with chronic iron overload from transfusions or hemolytic anemias.","oneSentence":"Captafer is an iron-chelating agent that binds and removes excess iron from the body to treat iron overload conditions.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:43:12.866Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic iron overload due to repeated blood transfusions (transfusional iron overload)"},{"name":"Iron overload in patients with chronic hemolytic anemias"}]},"trialDetails":[{"nctId":"NCT02774057","phase":"PHASE4","title":"Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD","status":"UNKNOWN","sponsor":"American University of Beirut Medical Center","startDate":"2016-03","conditions":"Iron Deficiency Anemia, Inflammatory Bowel Disease","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Captafer®","genericName":"Captafer®","companyName":"American University of Beirut Medical Center","companyId":"american-university-of-beirut-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Captafer is an iron-chelating agent that binds and removes excess iron from the body to treat iron overload conditions. Used for Chronic iron overload due to repeated blood transfusions (transfusional iron overload), Iron overload in patients with chronic hemolytic anemias.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}