{"id":"capsaicine-low-dose-0-04","safety":{"commonSideEffects":[{"rate":"common","effect":"Local burning or stinging at application site"},{"rate":"common","effect":"Erythema"},{"rate":"common","effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Capsaicin is a vanilloid compound that binds to and activates the transient receptor potential vanilloid 1 (TRPV1) channel on C-fiber nociceptors. Repeated or sustained exposure leads to desensitization of these pain-sensing neurons, reducing their ability to transmit pain signals. At low doses in topical formulations, this results in localized analgesia without systemic effects.","oneSentence":"Capsaicin activates TRPV1 nociceptors on nerve fibers, causing initial stimulation followed by desensitization and reduced pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:11.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (localized)"},{"name":"Postherpetic neuralgia"},{"name":"Musculoskeletal pain"}]},"trialDetails":[{"nctId":"NCT04967664","phase":"PHASE3","title":"Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery","status":"COMPLETED","sponsor":"Averitas Pharma, Inc.","startDate":"2021-07-13","conditions":"Post Surgical Neuropathic Pain","enrollment":409},{"nctId":"NCT06444919","phase":"PHASE4","title":"Capsaicin in Digital Osteoarthritis Versus Control","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2025-03-07","conditions":"Osteoarthritis Hand, Neuropathic Pain","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["control treatment"],"phase":"marketed","status":"active","brandName":"Capsaicine low dose 0.04 %","genericName":"Capsaicine low dose 0.04 %","companyName":"University Hospital, Clermont-Ferrand","companyId":"university-hospital-clermont-ferrand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Capsaicin activates TRPV1 nociceptors on nerve fibers, causing initial stimulation followed by desensitization and reduced pain signal transmission. Used for Neuropathic pain (localized), Postherpetic neuralgia, Musculoskeletal pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}