{"id":"capsaicin-topical-cream","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Local burning or stinging at application site"},{"rate":"10-30","effect":"Erythema (redness)"},{"rate":"5-20","effect":"Local irritation or pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Capsaicin is a natural alkaloid that binds to and activates the transient receptor potential vanilloid 1 (TRPV1) channel on nociceptive nerve fibers. Repeated or sustained exposure leads to desensitization of these nerve endings and depletion of substance P, a key neurotransmitter in pain signaling, resulting in localized analgesia. This mechanism makes it effective for topical pain relief in conditions involving peripheral neuropathic or musculoskeletal pain.","oneSentence":"Capsaicin activates TRPV1 pain receptors on nerve endings, causing initial stimulation followed by desensitization and depletion of substance P, reducing pain signal transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:45.961Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized neuropathic pain (post-herpetic neuralgia, diabetic neuropathy)"},{"name":"Musculoskeletal pain and arthritis"},{"name":"Topical pain relief"}]},"trialDetails":[{"nctId":"NCT03511846","phase":"PHASE1","title":"Pain Biomarker Study","status":"ENROLLING_BY_INVITATION","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-03-21","conditions":"Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia","enrollment":371},{"nctId":"NCT07260656","phase":"EARLY_PHASE1","title":"Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain","status":"NOT_YET_RECRUITING","sponsor":"Carilion Clinic","startDate":"2025-12","conditions":"Diabetic Neuropathies, Painful, Diabetic Foot, Diabetic Peripheral Neuropathy","enrollment":80},{"nctId":"NCT04283292","phase":"PHASE4","title":"Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2020-12-01","conditions":"Cannabinoid Hyperemesis Syndrome","enrollment":20},{"nctId":"NCT05649228","phase":"EARLY_PHASE1","title":"Thermosensitivity of a Topical Palmitated Formulation of Capsaicin","status":"COMPLETED","sponsor":"Carilion Clinic","startDate":"2022-12-13","conditions":"Pain Management","enrollment":52},{"nctId":"NCT05098067","phase":"PHASE2","title":"Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy","status":"COMPLETED","sponsor":"Women and Infants Hospital of Rhode Island","startDate":"2022-05-24","conditions":"Hyperemesis Gravidarum, Nausea Gravidarum, Vomiting of Pregnancy","enrollment":30},{"nctId":"NCT03464292","phase":"","title":"Spinal and Supra-Spinal Pain Mechanisms in Patients With Fibromyalgia","status":"COMPLETED","sponsor":"University of Florida","startDate":"2018-07-05","conditions":"Fibromyalgia, Pain","enrollment":55},{"nctId":"NCT03223350","phase":"PHASE2","title":"Topical Capsaicin for Cyclical Vomiting","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2017-12-20","conditions":"Cyclical Vomiting","enrollment":30},{"nctId":"NCT05029297","phase":"PHASE3","title":"Study With Two Capsaicin Topic Treatments in Diabetic Neuropathy.","status":"COMPLETED","sponsor":"Arafarma Group, S.A.","startDate":"2010-11-04","conditions":"Diabetic Neuropathy, Painful","enrollment":161},{"nctId":"NCT03944889","phase":"EARLY_PHASE1","title":"Quantitative Ultrasound Response of Capsaicin","status":"COMPLETED","sponsor":"Toronto Rehabilitation Institute","startDate":"2019-07-01","conditions":"Central Sensitisation","enrollment":20},{"nctId":"NCT04361149","phase":"PHASE4","title":"Motor Unit Abnormalities After Experimentally Induced Sensitization","status":"COMPLETED","sponsor":"Toronto Rehabilitation Institute","startDate":"2019-10-01","conditions":"Central Sensitisation, Motor Disorders","enrollment":23},{"nctId":"NCT03587220","phase":"NA","title":"A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2018-08-01","conditions":"Capsaicin, Ultaviolet B Light Burn, Neuropathic Pain","enrollment":44},{"nctId":"NCT03152578","phase":"PHASE2","title":"Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee","status":"COMPLETED","sponsor":"Panag Pharma Inc.","startDate":"2017-07-01","conditions":"Pain","enrollment":56},{"nctId":"NCT03146689","phase":"NA","title":"Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?","status":"COMPLETED","sponsor":"University of Nottingham","startDate":"2017-08-04","conditions":"Osteoarthritis, Knee","enrollment":22},{"nctId":"NCT03743896","phase":"PHASE4","title":"Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Lynk Biotechnologies Pte Ltd","startDate":"2016-05-18","conditions":"Osteoarthritis, Knee","enrollment":240},{"nctId":"NCT00655811","phase":"PHASE4","title":"Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2008-02","conditions":"Healthy","enrollment":40},{"nctId":"NCT02403687","phase":"","title":"Prospective Analgesic Compound Efficacy (PACE) Study","status":"COMPLETED","sponsor":"Express Specialty Pharmacy","startDate":"2015-06","conditions":"Arthritis, Tendonitis, Gout","enrollment":300},{"nctId":"NCT01231750","phase":"PHASE3","title":"Efficacy of Topical Capsaicin Cream for Stable Angina","status":"TERMINATED","sponsor":"Neal Weintraub","startDate":"2010-10","conditions":"Stable Angina","enrollment":7},{"nctId":"NCT01125215","phase":"PHASE2, PHASE3","title":"Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2009-09","conditions":"Painful Diabetic Neuropathy","enrollment":60},{"nctId":"NCT00916942","phase":"PHASE2","title":"Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN)","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2009-06","conditions":"Postherpetic Neuralgia","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chili"],"phase":"marketed","status":"active","brandName":"Capsaicin Topical Cream","genericName":"Capsaicin Topical Cream","companyName":"Women and Infants Hospital of Rhode Island","companyId":"women-and-infants-hospital-of-rhode-island","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Capsaicin activates TRPV1 pain receptors on nerve endings, causing initial stimulation followed by desensitization and depletion of substance P, reducing pain signal transmission. Used for Localized neuropathic pain (post-herpetic neuralgia, diabetic neuropathy), Musculoskeletal pain and arthritis, Topical pain relief.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}