{"id":"capsaicin-8","safety":{"commonSideEffects":[{"rate":"30–50","effect":"Application site erythema"},{"rate":"40–60","effect":"Application site burning/irritation"},{"rate":"10–20","effect":"Application site pruritus"},{"rate":"20–40","effect":"Transient increase in pain at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Capsaicin is a natural alkaloid that binds to and activates the transient receptor potential vanilloid 1 (TRPV1) channel on C-fiber nociceptors. Acute activation causes a burning sensation, but with sustained exposure, the nerve fibers become desensitized and substance P (a key pain neurotransmitter) becomes depleted, leading to prolonged analgesia in the treated area. 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