{"id":"cannabidiol-oral-solution-epidiolex","safety":{"commonSideEffects":[{"rate":"25-30","effect":"Somnolence"},{"rate":"20-25","effect":"Diarrhea"},{"rate":"15-20","effect":"Fatigue"},{"rate":"15-20","effect":"Decreased appetite"},{"rate":"10-15","effect":"Elevated liver transaminases"},{"rate":"5-10","effect":"Rash"},{"rate":"5-10","effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cannabidiol (CBD) is a non-intoxicating cannabinoid that acts through multiple mechanisms including modulation of transient receptor potential (TRP) channels, enhancement of adenosine signaling, and effects on serotonin receptors. It reduces seizure frequency and severity in epilepsy by decreasing neuronal excitability without direct GABA receptor agonism. The exact molecular mechanisms remain incompletely understood but involve both cannabinoid receptor-independent and receptor-dependent pathways.","oneSentence":"Cannabidiol modulates endocannabinoid signaling and multiple ion channels to reduce neuronal hyperexcitability and seizure activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:42.945Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dravet syndrome (severe myoclonic epilepsy of infancy)"},{"name":"Lennox-Gastaut syndrome"},{"name":"Tuberous sclerosis complex-associated seizures"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epidiolex"],"phase":"marketed","status":"active","brandName":"Cannabidiol Oral Solution [Epidiolex]","genericName":"Cannabidiol Oral Solution [Epidiolex]","companyName":"Silkiss Eye Surgery","companyId":"silkiss-eye-surgery","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cannabidiol modulates endocannabinoid signaling and multiple ion channels to reduce neuronal hyperexcitability and seizure activity. Used for Dravet syndrome (severe myoclonic epilepsy of infancy), Lennox-Gastaut syndrome, Tuberous sclerosis complex-associated seizures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}