{"id":"cannabidiol-and-caryophyllene-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or erythema at patch site"},{"rate":null,"effect":"Dizziness or drowsiness"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cannabidiol (CBD) is a non-intoxicating cannabinoid that interacts with multiple targets including TRPV1, 5-HT1A, and GPR55 receptors to reduce inflammation and pain signaling. β-Caryophyllene is a sesquiterpene that acts as a selective CB2 receptor agonist, enhancing anti-inflammatory and analgesic effects. The transdermal patch formulation allows sustained local and systemic delivery of both compounds.","oneSentence":"Cannabidiol and β-caryophyllene work synergistically through cannabinoid and terpene receptors to modulate pain, inflammation, and potentially neuropathic signaling.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:04:55.861Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain conditions (specific indication in Phase 3 trial not publicly detailed)"},{"name":"Neuropathic pain (potential)"}]},"trialDetails":[{"nctId":"NCT06099171","phase":"PHASE3","title":"Therapy With Paravertebral Oxygen-ozone Injections and Topical Cannabidiol and β-Caryophyllene Patch in Neck Pain","status":"UNKNOWN","sponsor":"Humanitas Clinical and Research Center","startDate":"2024-02-01","conditions":"Neck Pain","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Levotens Patch"],"phase":"phase_3","status":"active","brandName":"Cannabidiol and β-Caryophyllene Patch","genericName":"Cannabidiol and β-Caryophyllene Patch","companyName":"Humanitas Clinical and Research Center","companyId":"humanitas-clinical-and-research-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cannabidiol and β-caryophyllene work synergistically through cannabinoid and terpene receptors to modulate pain, inflammation, and potentially neuropathic signaling. Used for Chronic pain conditions (specific indication in Phase 3 trial not publicly detailed), Neuropathic pain (potential).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}