{"id":"canesten","safety":{"commonSideEffects":[{"rate":null,"effect":"Vulvovaginal irritation or burning"},{"rate":null,"effect":"Local erythema or pruritus"},{"rate":null,"effect":"Vaginal discharge"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":{"setId":"33102ed2-6885-2eb3-e054-00144ff8d46c","title":"CANESTEN V (CLOTRIMAZOL) CREAM [GENESIS IMPORTS & EXPORTS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Canesten contains clotrimazole, an imidazole antifungal that disrupts the synthesis of ergosterol, a critical component of fungal cell membranes. By inhibiting the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, clotrimazole causes accumulation of toxic sterol precursors and membrane instability, leading to fungal cell death. This mechanism is selective for fungal cells over human cells due to differences in sterol composition.","oneSentence":"Canesten inhibits fungal cell membrane synthesis by blocking ergosterol production through inhibition of lanosterol 14α-demethylase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:06.235Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal candidiasis"},{"name":"Dermatophyte infections (tinea pedis, tinea corporis, tinea cruris)"},{"name":"Cutaneous candidiasis"},{"name":"Pityriasis versicolor"}]},"trialDetails":[{"nctId":"NCT07311759","phase":"PHASE3","title":"Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-08-17","conditions":"Chronic Paronychia","enrollment":21},{"nctId":"NCT00769457","phase":"PHASE4","title":"OptiLink HF Study: Optimization of Heart Failure Management Using Medtronic OptiVol Fluid Status Monitoring and CareLink Network","status":"COMPLETED","sponsor":"Medtronic Cardiac Rhythm and Heart Failure","startDate":"2008-09","conditions":"Heart Failure","enrollment":1002},{"nctId":"NCT05916729","phase":"PHASE4","title":"Use of Maqui Berry Extract in Treating Oral Candidiasis in Diabetes Mellitus Patients and Systemically Healthy Persons","status":"UNKNOWN","sponsor":"University of Belgrade","startDate":"2021-05-01","conditions":"Oral Candidiases","enrollment":90},{"nctId":"NCT03896880","phase":"","title":"Detection of Bloodstream Pathogens in Hematological Malignancies","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-01-01","conditions":"Bloodstream Infection","enrollment":139},{"nctId":"NCT04813822","phase":"PHASE2","title":"Study Evaluating the Efficacy and Safety of Miconazole Nitrate + Domiphen Bromide Vaginal Cream in the Treatment of Subjects With Acute Vulvovaginal Candidiasis","status":"UNKNOWN","sponsor":"Aesculape CRO Belgium BV","startDate":"2021-09-13","conditions":"Acute Vulvovaginal Candidiasis","enrollment":90},{"nctId":"NCT00671528","phase":"PHASE4","title":"Safety and Efficacy of Quadriderme® in the Treatment of Impetiginous Eczema (Study P05134AM4)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2009-07","conditions":"Dermatitis, Atopic, Eczema, Atopic, Skin Diseases, Eczematous","enrollment":3},{"nctId":"NCT02582177","phase":"PHASE3","title":"Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis","status":"COMPLETED","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2019-06-11","conditions":"Tinea","enrollment":125},{"nctId":"NCT00385502","phase":"PHASE2","title":"A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail","status":"COMPLETED","sponsor":"Abeona Therapeutics, Inc","startDate":"2006-09","conditions":"Onychomycosis","enrollment":40},{"nctId":"NCT04317183","phase":"PHASE2","title":"Topical Chamomile in Preventing Chemotherapy-induced Oral Mucositis","status":"UNKNOWN","sponsor":"Hams Hamed Abdelrahman","startDate":"2019-05-15","conditions":"Oral Mucositis Due to Chemotherapy","enrollment":45},{"nctId":"NCT03115073","phase":"PHASE2, PHASE3","title":"ProF-001_Phase IIa","status":"COMPLETED","sponsor":"ProFem GmbH","startDate":"2017-04-04","conditions":"Vulvovaginal Candidiasis (VVC)","enrollment":84},{"nctId":"NCT03296436","phase":"EARLY_PHASE1","title":"A Pilot Study to Assess the Efficacy of NEOX® CORD 1K® in the Treatment of Complex Diabetic Wounds","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2020-01","conditions":"Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot), Diabetic Foot Ulcer, Diabetic Foot","enrollment":""},{"nctId":"NCT02515656","phase":"PHASE3","title":"Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2015-09","conditions":"Vaginitis","enrollment":661},{"nctId":"NCT03760276","phase":"PHASE1","title":"A Study to Evaluate the Appropriateness of the Voriconazole Dosing Regimen","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2018-08-20","conditions":"Fungal Infection","enrollment":11},{"nctId":"NCT02621905","phase":"PHASE4","title":"Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg","status":"COMPLETED","sponsor":"Mayne Pharma International Pty Ltd","startDate":"2015-11","conditions":"Neutropenia","enrollment":40},{"nctId":"NCT00526058","phase":"NA","title":"(H.E.L.P.)Apheresis Therapy to Compare the Reduction of LDL (Low Density Lipoprotein) Cholesterol","status":"COMPLETED","sponsor":"B. Braun Medical Inc.","startDate":"2007-08","conditions":"Hypercholesterolemia","enrollment":18},{"nctId":"NCT02635438","phase":"PHASE3","title":"A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.","status":"UNKNOWN","sponsor":"Thinq Pharma-CRO Pte. 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Used for Vaginal candidiasis, Dermatophyte infections (tinea pedis, tinea corporis, tinea cruris), Cutaneous candidiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}