{"id":"canephron-n","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions (rare)"},{"rate":null,"effect":"Photosensitivity (potential, due to Levistici radix)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Canephron N contains a standardized extract of three medicinal plants (Centaurii herba, Levistici radix, and Rosmarini folium) that work synergistically to promote urine flow, reduce urinary tract inflammation, and provide antimicrobial effects. The combination helps alleviate symptoms of urinary tract infections and supports overall renal health through its anti-inflammatory and diuretic mechanisms.","oneSentence":"Canephron N is a herbal combination that reduces inflammation and supports kidney and urinary tract function through diuretic and antimicrobial properties.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:50.066Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute and chronic urinary tract infections"},{"name":"Prevention of recurrent urinary tract infections"},{"name":"Supportive treatment of kidney and bladder conditions"}]},"trialDetails":[{"nctId":"NCT01478620","phase":"PHASE3","title":"Safety and Efficacy of Canephron® N in the Management of Uncomplicated Urinary Tract Infections (uUTI)","status":"COMPLETED","sponsor":"Bionorica SE","startDate":"2011-10","conditions":"Urinary Tract Infection","enrollment":125},{"nctId":"NCT02639520","phase":"PHASE3","title":"Efficacy of CLR Compared to Fosfomycin Trometamol in Acute Lower uUTIs","status":"COMPLETED","sponsor":"Bionorica SE","startDate":"2015-12","conditions":"Urinary Tract Infection","enrollment":659}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Canephron® N","genericName":"Canephron® N","companyName":"Bionorica SE","companyId":"bionorica-se","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Canephron N is a herbal combination that reduces inflammation and supports kidney and urinary tract function through diuretic and antimicrobial properties. Used for Acute and chronic urinary tract infections, Prevention of recurrent urinary tract infections, Supportive treatment of kidney and bladder conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}