{"id":"camazepam","rwe":[{"pmid":"30676597","year":"2019","title":"Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"},{"pmid":"22333515","year":"2012","title":"Benzodiazepines inhibit the acetylcholine receptor-operated potassium current (IK.ACh) by different mechanisms in guinea-pig atrial myocytes.","finding":"","journal":"The Journal of veterinary medical science","studyType":"Clinical Study"},{"pmid":"20172681","year":"2010","title":"Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"15329838","year":"2004","title":"Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.","finding":"","journal":"Journal of mass spectrometry : JMS","studyType":"Clinical Study"},{"pmid":"9264104","year":"1997","title":"Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.","finding":"","journal":"Pharmacology, biochemistry, and behavior","studyType":"Clinical Study"}],"tags":[{"label":"camazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BA15","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["camazepam"],"offLabel":[],"synonyms":["camazepam"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"camazepam","explanation":"Imagine your brain is like a busy city with lots of people talking and moving around. GABA is like a traffic cop that helps to slow down the traffic and keep everything calm. Camazepam helps the traffic cop to do its job more effectively, which can help to reduce anxiety and promote relaxation.","oneSentence":"Camazepam works by enhancing the activity of a neurotransmitter called GABA, which helps to calm the brain and reduce anxiety.","technicalDetail":"Camazepam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride channel opening and resulting in hyperpolarization of the neuronal membrane, which leads to a decrease in neuronal excitability and anxiolytic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/469","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CAMAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:12:14.547569","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"camazepam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"HZ3XRH03C3","INN_ID":"3500","UMLSCUI":"C0006795","ChEMBL_ID":"CHEMBL1095282","KEGG_DRUG":"D07315","DRUGBANK_ID":"DB01489","PUBCHEM_CID":"37367","MESH_SUPPLEMENTAL_RECORD_UI":"C084596"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":49,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA15","allCodes":["N05BA15"]},"biosimilarFilings":[],"recentPublications":[{"date":"2019 Feb 6","pmid":"30676597","title":"Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution.","journal":"Organic & biomolecular chemistry"},{"date":"2012 Jul","pmid":"22333515","title":"Benzodiazepines inhibit the acetylcholine receptor-operated potassium current (IK.ACh) by different mechanisms in guinea-pig atrial myocytes.","journal":"The Journal of veterinary medical science"},{"date":"2010 Aug 1","pmid":"20172681","title":"Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2004 Aug","pmid":"15329838","title":"Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.","journal":"Journal of mass spectrometry : JMS"},{"date":"1997 Sep","pmid":"9264104","title":"Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.","journal":"Pharmacology, biochemistry, and behavior"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"CAMAZEPAM","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Camazepam is a small molecule belonging to the drug class of camazepam. It is a benzodiazepine derivative, but its exact target and mechanism of action are unknown. Camazepam is used to treat anxiety and insomnia, although its commercial status and approved indications are unclear. As a camazepam, it is likely to have sedative and anxiolytic effects, but further research is needed to confirm its efficacy and safety. Its pharmacokinetic properties, such as half-life and bioavailability, are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}