{"id":"calcium-vitamine-d3","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Gastrointestinal upset (constipation, nausea)"},{"rate":null,"effect":"Kidney stone formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin D3 (cholecalciferol) increases intestinal absorption of dietary calcium and promotes bone mineralization, while also regulating parathyroid hormone secretion. Calcium serves as the structural mineral that is deposited into bone matrix under the influence of vitamin D3. Together, they maintain adequate serum calcium concentrations necessary for neuromuscular function, muscle contraction, and vascular tone.","oneSentence":"Calcium and Vitamin D3 work together to promote bone mineralization and maintain serum calcium levels by enhancing intestinal calcium absorption and regulating calcium-phosphate homeostasis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:36.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Calcium and vitamin D3 deficiency"},{"name":"Osteoporosis prevention and treatment"},{"name":"Hypoparathyroidism"},{"name":"Vitamin D deficiency"}]},"trialDetails":[{"nctId":"NCT01480869","phase":"PHASE3","title":"Study of Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients","status":"COMPLETED","sponsor":"Institut du Cancer de Montpellier - Val d'Aurelle","startDate":"2011-07","conditions":"Breast Cancer","enrollment":215},{"nctId":"NCT04100226","phase":"NA","title":"Vitamin D Deficiency and Effect of Its Supplementation on Interstitial Lung Diseases(ILD).","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-03-01","conditions":"Lung Diseases, Interstitial, Vitamin D Deficiency","enrollment":104},{"nctId":"NCT00447915","phase":"PHASE3","title":"Phase II/III Clinical Study of R484iv (Ibandronic Acid) for Primary Osteoporosis","status":"COMPLETED","sponsor":"Chugai Pharmaceutical","startDate":"2007-03","conditions":"Primary Osteoporosis","enrollment":1265},{"nctId":"NCT00460733","phase":"PHASE4","title":"SOLID-Effect of Risedronate Sodium at Distal Radius in Colle's Fracture.","status":"COMPLETED","sponsor":"Sanofi","startDate":"2007-03","conditions":"Colles' Fracture","enrollment":141}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Calcium & Vitamine D3","genericName":"Calcium & Vitamine D3","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium and cholecalciferol (Vitamin D3) are studied for various conditions, including breast cancer, primary osteoporosis, lung diseases, vitamin D deficiency, and Colles' fracture, according to ClinicalTrials.gov. Cholecalciferol, a small molecule with a mechanism as an HMG-CoA reductase inhibitor, is classified as an inhibitor drug, according to ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}