{"id":"calcium-phosphosilicate-putty-alloplast-graft","safety":{"commonSideEffects":[{"rate":null,"effect":"Minimal adverse events reported"},{"rate":null,"effect":"Potential for material displacement"},{"rate":null,"effect":"Infection at surgical site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This alloplast material provides a biocompatible scaffold that facilitates new bone formation through osteoconduction (physical guidance of bone growth along the material surface) and osteoinduction (stimulation of osteogenic cells). The calcium phosphosilicate composition releases ions that promote mineralization and integrate with native bone tissue, serving as a resorbable matrix that is gradually replaced by new bone.","oneSentence":"Calcium phosphosilicate putty acts as an osteoconductive and osteoinductive bone graft substitute that promotes bone regeneration and healing in dental and orthopedic applications.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:13.440Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone defect filling in dental and orthopedic surgery"},{"name":"Periodontal bone regeneration"},{"name":"Alveolar bone augmentation"}]},"trialDetails":[{"nctId":"NCT05484492","phase":"PHASE4","title":"Alveolar Ridge Preservation With Putty Allograft vs. Putty Alloplast Graft","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2022-10-06","conditions":"Alveolar Bone Resorption","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NovaBone, Osteogenics"],"phase":"marketed","status":"active","brandName":"calcium phosphosilicate putty alloplast graft","genericName":"calcium phosphosilicate putty alloplast graft","companyName":"University of Louisville","companyId":"university-of-louisville","modality":"Biologic","firstApprovalDate":"","aiSummary":"Calcium phosphosilicate putty acts as an osteoconductive and osteoinductive bone graft substitute that promotes bone regeneration and healing in dental and orthopedic applications. Used for Bone defect filling in dental and orthopedic surgery, Periodontal bone regeneration, Alveolar bone augmentation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}