{"id":"calcium-pantothenate","rwe":[{"pmid":"41762802","year":"2026","title":"Rapid detection of five B vitamins based on surface-enhanced Raman spectroscopy and density functional theory analyses.","finding":"","journal":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","studyType":"Clinical Study"},{"pmid":"40750648","year":"2025","title":"Improved conservation of callus and rhizome microcuttings of Podophyllum hexandrum germplasm using the slow growth storage approach.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"39438646","year":"2024","title":"Hydration behavior of D-calcium pantothenate (vitamin B5) in the presence of sugar-based deep eutectic solvents at different temperatures: experimental and theoretical study.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"38820824","year":"2024","title":"A stability-indicating HPLC assay of ten different vitamins in a food supplement: Appraisal of the method's greenness, whiteness, and blueness.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"37732546","year":"2023","title":"Design of experiments for micellar electrokinetic chromatography method development for the monitoring of water-soluble vitamins in cell culture medium.","finding":"","journal":"Electrophoresis","studyType":"Clinical Study"}],"_fda":{"id":"b6743f78-a3c4-452e-97c5-ab8e2af7f232","set_id":"635104e6-6a53-4684-ac9a-7ac31b33083d","openfda":{"nui":["N0000193618","M0001797","M0022797","N0000175952","M0022794","N0000175951"],"unii":["WR1WPI7EW8","PQ6CK8PD0R","H0G9379FGK","568ET80C3D","1C6V77QF41","P6YC3EG204","F05Q2T2JA0","R5L488RY0Q","935E97BOY8","25X51I8RD4","68Y4CF58BV","TLM2976OFR","X66NSO3N35","SOI2LOH54Z"],"route":["ORAL"],"rxcui":["1313925"],"spl_id":["b6743f78-a3c4-452e-97c5-ab8e2af7f232"],"brand_name":["Se-Natal 19"],"spl_set_id":["635104e6-6a53-4684-ac9a-7ac31b33083d"],"package_ndc":["13925-116-01"],"product_ndc":["13925-116"],"generic_name":[".BETA.-CAROTENE, ASCORBIC ACID, CHOLECALCIFEROL, .ALPHA.-TOCOPHEROL ACETATE, DL-, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE HYDROCHLORIDE, FOLIC ACID, CYANOCOBALAMIN, CALCIUM PANTOTHENATE, CALCIUM CARBONATE, FERROUS FUMARATE, ZINC OXIDE AND DOCUSATE SODIUM"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]","Vitamin D [CS]","Vitamin B 12 [CS]"],"substance_name":[".ALPHA.-TOCOPHEROL ACETATE, DL-",".BETA.-CAROTENE","ASCORBIC ACID","CALCIUM CARBONATE","CALCIUM PANTOTHENATE","CHOLECALCIFEROL","CYANOCOBALAMIN","DOCUSATE SODIUM","FERROUS FUMARATE","FOLIC ACID","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","THIAMINE","ZINC OXIDE"],"pharm_class_epc":["Vitamin C [EPC]","Vitamin D [EPC]","Vitamin B12 [EPC]"],"manufacturer_name":["Seton Pharmaceuticals"],"is_original_packager":[true]},"version":"9","warnings":["WARNINGS Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B 12 is deficient. WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately."],"overdosage":["OVERDOSAGE ​Symptoms: Abdominal pain, metabolic acidosis, anuria, CNS damage, coma, convulsions, death, dehydration, diffuse vascular congestion, hepatic cirrhosis, hypotension, hypothermia, lethargy, nausea, vomiting, diarrhea, tarry stools, melena, hematemesis, tachycardia, hyperglycemia, drowsiness, pallor, cyanosis, lassitude, seizures, and shock."],"description":["DESCRIPTION Se-Natal 19 is a white, oblong, film coated tablet, debossed \"TL 019\". Each film coated tablet contains: Supplement Facts ​Servings per Bottle: ​ 100 ​Serving Size: ​ 1 tablet ​Each Tablet contains: ​% DV for Pregnant and Lactating Women Vitamin A (as beta carotene) 1000 IU 23% Vitamin C (ascorbic acid) 100 mg 83% Vitamin D (as cholecalciferol) 10 mcg 67% Vitamin E (as dl-alpha tocoperol acetate) 30 IU 142% Thiamine (Vitamin B ​1 ​) 3 mg 214% Riboflavin (Vitamin B ​2 ​) 3 mg 188% Niacin (as niacinamide) 15 mg 83% Vitamin B ​6 ​ (as pyridoxine HCl) 20 mg 1000% Folate (folic acid) 1000 mcg 167% Vitamin B ​12 ​ (as cyanocobalamin) 12 mcg 429% Pantothenic Acid (as calcium pantothenate) 7 mg 100% Calcium (as calcium carbonate) 200 mg 15% Iron (as ferrous fumarate) 29 mg 107% Zinc (as zinc oxide) 20 mg 154%"],"precautions":["PRECAUTIONS General Take 2 hours after meals. Do not exceed recommended dose. Discontinue use if symptoms of intolerance appear. Folic Acid Folic acid in doses above 0.1 mg daily may obscure pernicious anemia, in that hematologic remission can occur while neurological manifestations remain progressive. ​Pediatric Use Safety and effectiveness in pediatric patients have not been established. ​Geriatric Use Dosing for elderly patients should be cautious. Due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy, dosing should start at the lower end of the dosing range."],"how_supplied":["​HOW SUPPLIED Se-Natal 19 tablets for oral administration are supplied as white, coated, oblong tablets debossed \"TL019\", packaged in bottles of 100 tablets. Product Code: 13925-116-01."],"boxed_warning":["WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately."],"effective_time":"20250224","adverse_reactions":["​ADVERSE REACTIONS Adverse reactions with iron therapy may include GI irritation, constipation, diarrhea, nausea, vomiting, and dark stools. Adverse reactions with iron therapy are usually transient. Allergic sensitization has been reported following both oral and parenteral administration of folic acid."],"contraindications":["CONTRAINDICATIONS This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."],"description_table":["
Supplement Facts
​Servings per Bottle:​ 100
​Serving Size:​ 1 tablet
​Each Tablet contains:​% DV for Pregnant and Lactating Women
Vitamin A (as beta carotene)1000 IU23%
Vitamin C (ascorbic acid)100 mg83%
Vitamin D (as cholecalciferol)10 mcg67%
Vitamin E (as dl-alpha tocoperol acetate)30 IU142%
Thiamine (Vitamin B​1​)3 mg214%
Riboflavin (Vitamin B​2​)3 mg188%
Niacin (as niacinamide)15 mg83%
Vitamin B​6​ (as pyridoxine HCl)20 mg1000%
Folate (folic acid)1000 mcg167%
Vitamin B​12​ (as cyanocobalamin)12 mcg 429%
Pantothenic Acid (as calcium pantothenate) 7 mg 100%
Calcium (as calcium carbonate)200 mg15%
Iron (as ferrous fumarate)29 mg107%
Zinc (as zinc oxide)20 mg 154%
"],"drug_interactions":["DRUG INTERACTIONS Prescriber should be aware of a number of iron/drug interactions, including antacids, tetracyclines, or fluoroquinolones."],"inactive_ingredient":["OTHER INGREDIENTS Acacia, Croscarmellose Sodium, Fumed Silica, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polyvinyl Alcohol, Stearic Acid, Talc and Titanium Dioxide."],"storage_and_handling":["STORAGE Store at 20° - 25°C (68° - 77°F), excursions permitted to 15° - 30°C (59° - 86°F) [See USP controlled room temperature]."],"indications_and_usage":["INDICATIONS Se-Natal 19 tablets are indicated for use in improving the nutritional status of women throughout pregnancy and in the postnatal period for both lactating and non-lactating mothers. Se-Natal 19 tablets are also useful in improving the nutritional status of women prior to conception."],"spl_unclassified_section":["Vitamins & Minerals with Folic Acid R x Only","​NOTICE Contact with moisture can discolor or erode the tablet. Do not chew tablet.","PHARMACIST Dispense in a tight, light-resistant container as defined in the USP/NF with child-resistant closure. Call your doctor about side effects. You may report side effects to FDA at 1-800-FDA-1088.","All prescriptions using this product shall be pursuant to state statutes as applicable. This is not an Orange Book product. This product may be administered only under a physician's supervision. There are no implied or explicit claims on therapeutic equivalence. Reserved for Professional Recommendation. KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. R x Only Manufactured For: Seton Pharmaceuticals Manasquan, NJ 08736 1-800-510-3401 MADE IN CANADA Code 116-01 Rev. 03/18 SETON PHARMACEUTICALS"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION One tablet daily, or as directed by a physician."],"spl_product_data_elements":["Se-Natal 19 .beta.-carotene, ascorbic acid, cholecalciferol, .alpha.-tocopherol acetate, dl-, thiamine, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, cyanocobalamin, calcium pantothenate, calcium carbonate, ferrous fumarate, zinc oxide and docusate sodium .BETA.-CAROTENE .BETA.-CAROTENE ASCORBIC ACID ASCORBIC ACID CHOLECALCIFEROL CHOLECALCIFEROL .ALPHA.-TOCOPHEROL ACETATE, DL- .ALPHA.-TOCOPHEROL, DL- THIAMINE THIAMINE ION RIBOFLAVIN RIBOFLAVIN NIACINAMIDE NIACINAMIDE PYRIDOXINE HYDROCHLORIDE PYRIDOXINE FOLIC ACID FOLIC ACID CYANOCOBALAMIN CYANOCOBALAMIN CALCIUM PANTOTHENATE PANTOTHENIC ACID CALCIUM CARBONATE CALCIUM CATION FERROUS FUMARATE FERROUS CATION ZINC OXIDE ZINC CATION DOCUSATE SODIUM DOCUSATE ACACIA CROSCARMELLOSE SODIUM SILICON DIOXIDE HYPROMELLOSES MAGNESIUM STEARATE CELLULOSE, MICROCRYSTALLINE POLYETHYLENE GLYCOL, UNSPECIFIED POLYVINYL ALCOHOL STEARIC ACID TALC TITANIUM DIOXIDE TL019"],"package_label_principal_display_panel":["PACKAGE LABEL.PRINCIPAL DISPLAY PANEL NDC 13925- 116 -01 Se-Natal 19 Tablets Vitamins and Minerals with Folic Acid 100 Tablets R x Only SETON PHARMACEUTICALS PRINCIPAL DISPLAY PANEL - 100 tablets"]},"tags":[{"label":"Small Molecule","category":"modality"},{"label":"A11HA31","category":"atc"},{"label":"Oral","category":"route"},{"label":"Topical","category":"route"},{"label":"Capsule","category":"form"},{"label":"Liquid","category":"form"},{"label":"Active","category":"status"},{"label":"Ascorbic acid deficiency","category":"indication"},{"label":"Pantothenic acid deficiency","category":"indication"},{"label":"Hospira","category":"company"},{"label":"Approved 1990s","category":"decade"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamin B Complex","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":["WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately."],"safetySignals":[{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"8 reports"},{"date":"","signal":"EMOTIONAL DISTRESS","source":"FDA FAERS","actionTaken":"7 reports"},{"date":"","signal":"ANXIETY","source":"FDA FAERS","actionTaken":"6 reports"},{"date":"","signal":"ANHEDONIA","source":"FDA FAERS","actionTaken":"5 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"5 reports"},{"date":"","signal":"BACK PAIN","source":"FDA FAERS","actionTaken":"4 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"4 reports"},{"date":"","signal":"ECONOMIC PROBLEM","source":"FDA FAERS","actionTaken":"4 reports"},{"date":"","signal":"OSTEOPOROSIS","source":"FDA FAERS","actionTaken":"4 reports"},{"date":"","signal":"ALOPECIA","source":"FDA FAERS","actionTaken":"3 reports"}],"commonSideEffects":[{"effect":"Gastrointestinal disturbances","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Allergic sensitizations","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Anorexia","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Nausea","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Diarrhea","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Constipation","drugRate":"","severity":"common","_validated":false,"_confidence":0.3}],"contraindications":["Anemia due to enzyme deficiency","Hb SS disease","Hemochromatosis","Kidney disease","Primary hyperoxaluria"],"specialPopulations":{"Geriatric use":"No clinical studies have been performed in patients age 65 and over to determine whether older persons respond differently from younger persons. Dosage should always begin at the low end of the dosage scale and should consider that elderly persons may have decreased hepatic, renal, or cardiac function and or concomitant diseases.","Paediatric use":"Safety and effectiveness of this product have not been established in pediatric patients."}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CALCIUM PANTOTHENATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:13:13.993713+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Calcium Pantothenate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:13:21.677681+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:13:20.016468+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CALCIUM PANTOTHENATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:13:20.310762+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:13:12.626916+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:13:12.626945+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (boxed_warning)","rawText":"WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:13:12.626954+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:13:22.084630+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1901349/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:13:21.324661+00:00"}},"allNames":"vitamin b5","offLabel":[],"synonyms":["calcium pantothenate","pantothenic acid","(+)-Pantothenic acid","D-Pantothenic acid","Vitamin B5"],"timeline":[{"date":"1993-12-29","type":"positive","source":"DrugCentral","milestone":"FDA approval (Hospira)"}],"brandName":"Vitamin B5","ecosystem":[{"indication":"Ascorbic acid deficiency","otherDrugs":[{"name":"ascorbic acid","slug":"ascorbic-acid","company":""},{"name":"zinc gluconate","slug":"zinc-gluconate","company":""}],"globalPrevalence":null},{"indication":"Pantothenic acid deficiency","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Calcium Pantothenate acts as a coenzyme for acyl carrier protein, facilitating the transfer of acyl groups in fatty acid synthesis and other metabolic pathways."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Pantothenic_acid","title":"Pantothenic acid","extract":"Pantothenic acid (vitamin B5) is a B vitamin and an essential nutrient. All animals need pantothenic acid in order to synthesize coenzyme A (CoA), which is essential for cellular energy production and for the synthesis and degradation of proteins, carbohydrates, and fats.","wiki_history":"==History==\n\nThe term vitamin is derived from the word vitamine, which was coined in 1912 by Polish biochemist Casimir Funk, who isolated a complex of water-soluble micronutrients essential to life, all of which he presumed to be amines. When this presumption was later determined not to be true, the \"e\" was dropped from the name, hence \"vitamin\". Vitamin nomenclature was alphabetical, with Elmer McCollum calling these fat-soluble A and water-soluble B. Three years later Elvehjem and Jukes demonstrated that it was a growth and anti-dermatitis factor in chickens. Williams dubbed the compound \"pantothenic acid\", deriving the name from the Greek word pantothen, which translates as \"from everywhere\". 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