{"id":"calcium-levulinate","rwe":[{"pmid":"35049880","year":"2021","title":"Mussel Shells, a Valuable Calcium Resource for the Pharmaceutical Industry.","finding":"","journal":"Marine drugs","studyType":"Clinical Study"},{"pmid":"30241813","year":"2018","title":"Versatile acid base sustainable solvent for fast extraction of various molecular weight chitin from lobster shell.","finding":"","journal":"Carbohydrate polymers","studyType":"Clinical Study"},{"pmid":"25995864","year":"2015","title":"Crystal structure of a polymeric calcium levulinate dihydrate: catena-poly[[di-aqua-calcium]-bis-(μ2-4-oxo-butano-ato)].","finding":"","journal":"Acta crystallographica. Section E, Crystallographic communications","studyType":"Clinical Study"},{"pmid":"24874995","year":"2014","title":"Calcium-43 chemical shift and electric field gradient tensor interplay: a sensitive probe of structure, polymorphism, and hydration.","finding":"","journal":"Physical chemistry chemical physics : PCCP","studyType":"Clinical Study"},{"pmid":"23171137","year":"2013","title":"Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.","finding":"","journal":"Chemical research in toxicology","studyType":"Clinical Study"}],"tags":[{"label":"calcium levulinate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12AA30","category":"atc"},{"label":"Active","category":"status"},{"label":"Hypocalcemia","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"calcium laevulate","offLabel":[],"synonyms":["calcium levulinate","calcium laevulate"],"timeline":[],"brandName":"Calcium Laevulate","ecosystem":[{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"calcium levulinate","explanation":"Think of calcium levulinate like a calcium supplement. When you have low calcium levels, your body needs a boost to get back to normal. Calcium levulinate helps by providing extra calcium that your body can use to regulate various functions, such as muscle and nerve function.","oneSentence":"Calcium levulinate works by replenishing calcium stores in the body.","technicalDetail":"Calcium levulinate acts as a calcium supplement, replenishing calcium stores in the body by increasing serum calcium levels, which is essential for various physiological processes, including muscle contraction, nerve transmission, and bone mineralization."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4844","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=calcium%20levulinate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium levulinate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:07:49.221482","biosimilars":[],"competitors":[{"drugName":"calcium phosphate","drugSlug":"calcium-phosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium gluconate","drugSlug":"calcium-gluconate","fdaApproval":"","patentExpiry":"Jul 25, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"calcium carbonate","drugSlug":"calcium-carbonate","fdaApproval":"2000-10-16","relationship":"same-class"},{"drugName":"calcium chloride","drugSlug":"calcium-chloride","fdaApproval":"1971-03-22","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"calcium glycerylphosphate","drugSlug":"calcium-glycerylphosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium glucoheptonate","drugSlug":"calcium-glucoheptonate","fdaApproval":"1972-12-04","relationship":"same-class"},{"drugName":"calcium citrate","drugSlug":"calcium-citrate","fdaApproval":"","relationship":"same-class"}],"genericName":"calcium levulinate","indications":{"approved":[{"name":"Hypocalcemia","source":"DrugCentral","snomedId":5291005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"calcium-phosphate","brandName":"calcium phosphate","genericName":"calcium phosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-gluconate","brandName":"calcium gluconate","genericName":"calcium gluconate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-carbonate","brandName":"calcium carbonate","genericName":"calcium carbonate","approvalYear":"2000","relationship":"same-class"},{"drugId":"calcium-chloride","brandName":"calcium chloride","genericName":"calcium chloride","approvalYear":"1971","relationship":"same-class"},{"drugId":"calcium-glycerylphosphate","brandName":"calcium glycerylphosphate","genericName":"calcium glycerylphosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-glucoheptonate","brandName":"calcium glucoheptonate","genericName":"calcium glucoheptonate","approvalYear":"1972","relationship":"same-class"},{"drugId":"calcium-citrate","brandName":"calcium citrate","genericName":"calcium citrate","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07149649","phase":"PHASE2,PHASE3","title":"Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC)","status":"NOT_YET_RECRUITING","sponsor":"Swiss Cancer Institute","startDate":"2026-07","conditions":["Metastatic NSCLC - Non-Small Cell Lung Cancer"],"enrollment":230,"completionDate":"2035-03-31"},{"nctId":"NCT06876038","phase":"PHASE2","title":"Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions","status":"NOT_YET_RECRUITING","sponsor":"University of Massachusetts, Boston","startDate":"2026-09","conditions":["Oral Cancer","Oral Cavity Cancer","Oral Leukoplakia","Oral Lichen Planus","Oral Squamous Cell Carcinoma"],"enrollment":65,"completionDate":"2028-12"},{"nctId":"NCT06307548","phase":"PHASE1,PHASE2","title":"Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer","status":"SUSPENDED","sponsor":"Roswell Park Cancer Institute","startDate":"2024-07-30","conditions":["Locally Advanced Colorectal Carcinoma","Recurrent Colorectal Carcinoma","Stage III Colorectal Cancer"],"enrollment":21,"completionDate":"2027-06-01"},{"nctId":"NCT04223570","phase":"","title":"Portable Measurement of Protoporphyrin IX in the Skin","status":"COMPLETED","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2022-12-01","conditions":["Photodynamic Therapy","Protoporphyrin IX"],"enrollment":219,"completionDate":"2025-05-20"},{"nctId":"NCT03088852","phase":"PHASE4","title":"Magnesium Deficiency In Patients Hospitalized in Internal Medicine Wards","status":"RECRUITING","sponsor":"Frieda Wolf","startDate":"2017-05-10","conditions":["Hypomagnesemia"],"enrollment":330,"completionDate":"2026-12"},{"nctId":"NCT03398382","phase":"PHASE1,PHASE2","title":"Effect of Oral Magnesium on Anesthesia and Postoperative Analgesia After Surgical Removal of the Lower Third Molars.","status":"UNKNOWN","sponsor":"Daniel Jerković","startDate":"2017-04-15","conditions":["Postoperative Pain","Third Molar","Postoperative Complications"],"enrollment":80,"completionDate":"2019-06-15"},{"nctId":"NCT01310868","phase":"PHASE2","title":"Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma","status":"COMPLETED","sponsor":"University College, London","startDate":"2011-05","conditions":["Glioblastoma"],"enrollment":59,"completionDate":"2015-03"},{"nctId":"NCT02101931","phase":"PHASE3","title":"A Laser Detection for Bladder Cancer by (Photodynamic) Spectra of Urine","status":"COMPLETED","sponsor":"Princess Al-Johara Al-Ibrahim Cancer Research Center","startDate":"2014-03","conditions":["Transitional Cell Carcinoma of the Bladder"],"enrollment":100,"completionDate":"2016-03"},{"nctId":"NCT00002963","phase":"PHASE2","title":"Photodynamic Therapy in Treating Patients With Skin Cancer","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"1993-11","conditions":["Non-melanomatous Skin Cancer"],"enrollment":0,"completionDate":"2007-06"},{"nctId":"NCT00994006","phase":"PHASE4","title":"The Absorption of Magnesium Oxide Compared to Citrate in Healthy Subjects","status":"COMPLETED","sponsor":"Sheba Medical Center","startDate":"2010-01","conditions":["Healthy Subjects","Hypomagnesemia"],"enrollment":41,"completionDate":"2011-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000147255","NDDF":"000780","UNII":"T6133SO781","VUID":"4018976","VANDF":"4018976","RXNORM":"47624","UMLSCUI":"C0108124","ChEMBL_ID":"CHEMBL2106516","KEGG_DRUG":"D03298","DRUGBANK_ID":"DB13800","PUBCHEM_CID":"7533"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Bone"],"atcClassification":{"source":"DrugCentral","atcCode":"A12AA30","allCodes":["A12AA30"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Dec 24","pmid":"35049880","title":"Mussel Shells, a Valuable Calcium Resource for the Pharmaceutical Industry.","journal":"Marine drugs"},{"date":"2018 Dec 1","pmid":"30241813","title":"Versatile acid base sustainable solvent for fast extraction of various molecular weight chitin from lobster shell.","journal":"Carbohydrate polymers"},{"date":"2015 May 1","pmid":"25995864","title":"Crystal structure of a polymeric calcium levulinate dihydrate: catena-poly[[di-aqua-calcium]-bis-(μ2-4-oxo-butano-ato)].","journal":"Acta crystallographica. Section E, Crystallographic communications"},{"date":"2014 Jul 14","pmid":"24874995","title":"Calcium-43 chemical shift and electric field gradient tensor interplay: a sensitive probe of structure, polymorphism, and hydration.","journal":"Physical chemistry chemical physics : PCCP"},{"date":"2013 Feb 18","pmid":"23171137","title":"Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.","journal":"Chemical research in toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Calcium levulinate is a small molecule drug in the calcium levulinate class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat hypocalcemia, a condition characterized by abnormally low calcium levels in the blood. The commercial status of calcium levulinate is unknown, and it may be patented or generic. Key safety considerations include unknown bioavailability and half-life. Calcium levulinate is FDA approved for the treatment of hypocalcemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}