{"id":"calcium-glycerylphosphate","rwe":[],"tags":[{"label":"calcium glycerylphosphate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12AA08","category":"atc"},{"label":"Topical","category":"route"},{"label":"Dental","category":"route"},{"label":"Paste","category":"form"},{"label":"Active","category":"status"},{"label":"Cardiac arrest","category":"indication"},{"label":"Disorder of electrolytes","category":"indication"},{"label":"Hyperkalemia","category":"indication"},{"label":"Hypermagnesemia","category":"indication"},{"label":"Hypocalcemia","category":"indication"},{"label":"Hypocalcemic tetany","category":"indication"}],"phase":"marketed","safety":{"contraindications":["Dehydration","End stage renal disease","Heart disease","Humoral hypercalcemia of malignancy","Hypercalcemia","Hypercalciuria","Hyperparathyroidism","Kidney disease","Kidney stone","Poisoning by digitalis glycoside","Sarcoidosis","Ventricular fibrillation"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=calcium glycerylphosphate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:02:28.014972+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:02:44.153901+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:02:35.030985+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium glycerylphosphate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:02:35.780968+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200668/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:02:36.338345+00:00"}},"allNames":"calcium glycerophosphate","offLabel":[],"synonyms":["calcium glycerylphosphate","calcium glycerophosphate"],"timeline":[],"aiSummary":"Calcium Glycerophosphate is a mineral supplement that has been studied in various clinical trials for its use in dental applications, including pits and fissure sealants and toothpaste. It is a small molecule that acts as an inhibitor of HMG-CoA reductase, a key enzyme in cholesterol synthesis.","brandName":"Calcium Glycerophosphate","ecosystem":[{"indication":"Cardiac arrest","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glucoheptonate","slug":"calcium-glucoheptonate","company":"Abbott"},{"name":"isoprenaline","slug":"isoprenaline","company":""}],"globalPrevalence":null},{"indication":"Disorder of electrolytes","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glucoheptonate","slug":"calcium-glucoheptonate","company":"Abbott"}],"globalPrevalence":null},{"indication":"Hyperkalemia","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glucoheptonate","slug":"calcium-glucoheptonate","company":"Abbott"},{"name":"patiromer calcium","slug":"patiromer-calcium","company":"Relypsa Inc"}],"globalPrevalence":null},{"indication":"Hypermagnesemia","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glucoheptonate","slug":"calcium-glucoheptonate","company":"Abbott"}],"globalPrevalence":null},{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Hypocalcemic tetany","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glucoheptonate","slug":"calcium-glucoheptonate","company":"Abbott"},{"name":"calcium gluconate","slug":"calcium-gluconate","company":""}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"calcium glycerylphosphate","explanation":"","oneSentence":"","technicalDetail":"Calcium Glycerophosphate works by increasing serum calcium levels, which is essential for maintaining proper cardiac function, nerve transmission, and muscle contraction. It does this by replenishing calcium stores in the body, which can become depleted due to various conditions, such as cardiac arrest, hyperkalemia, and hypocalcemia."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4434","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium glycerylphosphate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:11:44.046042","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:02:44.154349+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"calcium phosphate","drugSlug":"calcium-phosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium gluconate","drugSlug":"calcium-gluconate","fdaApproval":"","patentExpiry":"Jul 25, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"calcium carbonate","drugSlug":"calcium-carbonate","fdaApproval":"2000-10-16","relationship":"same-class"},{"drugName":"calcium chloride","drugSlug":"calcium-chloride","fdaApproval":"1971-03-22","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"calcium glucoheptonate","drugSlug":"calcium-glucoheptonate","fdaApproval":"1972-12-04","relationship":"same-class"},{"drugName":"calcium citrate","drugSlug":"calcium-citrate","fdaApproval":"","relationship":"same-class"}],"genericName":"calcium glycerylphosphate","indications":{"approved":[{"name":"Cardiac arrest","source":"DrugCentral","snomedId":410429000,"regulator":"FDA","eligibility":"No information available"},{"name":"Disorder of electrolytes","source":"DrugCentral","snomedId":237840007,"regulator":"FDA","eligibility":"No information available"},{"name":"Hyperkalemia","source":"DrugCentral","snomedId":14140009,"regulator":"FDA","eligibility":"No information available"},{"name":"Hypermagnesemia","source":"DrugCentral","snomedId":66978005,"regulator":"FDA","eligibility":"No information available"},{"name":"Hypocalcemia","source":"DrugCentral","snomedId":5291005,"regulator":"FDA","eligibility":"No information available"},{"name":"Hypocalcemic tetany","source":"DrugCentral","snomedId":190869004,"regulator":"FDA","eligibility":"No information available"}],"offLabel":[{"name":"Neonatal hypocalcemic tetany","source":"DrugCentral","drugName":"calcium glycerylphosphate","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"calcium-phosphate","brandName":"calcium phosphate","genericName":"calcium phosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-gluconate","brandName":"calcium gluconate","genericName":"calcium gluconate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-carbonate","brandName":"calcium carbonate","genericName":"calcium carbonate","approvalYear":"2000","relationship":"same-class"},{"drugId":"calcium-chloride","brandName":"calcium chloride","genericName":"calcium chloride","approvalYear":"1971","relationship":"same-class"},{"drugId":"calcium-glucoheptonate","brandName":"calcium glucoheptonate","genericName":"calcium glucoheptonate","approvalYear":"1972","relationship":"same-class"},{"drugId":"calcium-citrate","brandName":"calcium citrate","genericName":"calcium citrate","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical, Dental","formulation":"Paste","formulations":[{"form":"PASTE","route":"DENTAL","productName":"Perioe lucky fresh - breath care"},{"form":"PASTE","route":"DENTAL","productName":"Perioe lucky fresh - cavity care"},{"form":"PASTE, DENTIFRICE","route":"TOPICAL","productName":"DR.CHOIS TOOTHPASTE STEP TWO KIDS"}]},"crossReferences":{"NUI":"N0000178896","MMSL":"23892","NDDF":"000778","UNII":"XWV9Z12C1C","VUID":"4019182","CHEBI":"CHEBI:31336","VANDF":"4017701","RXNORM":"1909","UMLSCUI":"C3652644","chemblId":"CHEMBL1200668","ChEMBL_ID":"CHEMBL3707206","KEGG_DRUG":"D01488","DRUGBANK_ID":"DB11264","PUBCHEM_CID":"62820","MESH_DESCRIPTOR_UI":"D005994"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"A12AA08","allCodes":["A12AA08"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:02:44.154349+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}