{"id":"calcium-glucoheptonate","rwe":[{"pmid":"32302064","year":"2020","title":"Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium carbonate.","finding":"","journal":"Pharmacology research & perspectives","studyType":"Clinical Study"},{"pmid":"31498830","year":"2019","title":"Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro.","finding":"","journal":"PloS one","studyType":"Clinical Study"},{"pmid":"30100514","year":"2018","title":"Short communication: The effect of calcium supplementation at calving on neutrophil function.","finding":"","journal":"Journal of dairy science","studyType":"Clinical Study"},{"pmid":"10576416","year":"1999","title":"Effects of estradiol and calcium on gonadotrophic cells in middle-aged female rats.","finding":"","journal":"The Histochemical journal","studyType":"Clinical Study"},{"pmid":"9587629","year":"1998","title":"Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium.","finding":"","journal":"Acta histochemica","studyType":"Clinical Study"}],"tags":[{"label":"calcium glucoheptonate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12AA10","category":"atc"},{"label":"Intravenous","category":"route"},{"label":"Injection","category":"form"},{"label":"Active","category":"status"},{"label":"Cardiac arrest","category":"indication"},{"label":"Disorder of electrolytes","category":"indication"},{"label":"Hyperkalemia","category":"indication"},{"label":"Hypermagnesemia","category":"indication"},{"label":"Hypocalcemia","category":"indication"},{"label":"Hypocalcemic tetany","category":"indication"},{"label":"Abbott","category":"company"},{"label":"Approved 1970s","category":"decade"}],"phase":"marketed","safety":{"contraindications":["End stage renal disease","Heart disease","Humoral hypercalcemia of malignancy","Hypercalcemia","Hypercalciuria","Kidney disease","Kidney stone","Poisoning by digitalis glycoside","Sarcoidosis","Ventricular fibrillation"]},"trials":[],"aliases":[],"company":"Abbott","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=calcium glucoheptonate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:50:06.677969+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Calcium Glucoheptonate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:50:13.781025+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:50:12.161536+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium glucoheptonate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:50:12.486355+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4303148/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:50:13.424136+00:00"}},"allNames":"calcium gluceptate","offLabel":[],"synonyms":["calcium glucoheptonate","calcium heptagluconate","calcium gluceptate"],"timeline":[{"date":"1972-12-04","type":"positive","source":"DrugCentral","milestone":"FDA approval (Abbott)"}],"brandName":"Calcium Gluceptate","ecosystem":[{"indication":"Cardiac arrest","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glycerylphosphate","slug":"calcium-glycerylphosphate","company":""},{"name":"isoprenaline","slug":"isoprenaline","company":""}],"globalPrevalence":null},{"indication":"Disorder of electrolytes","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glycerylphosphate","slug":"calcium-glycerylphosphate","company":""}],"globalPrevalence":null},{"indication":"Hyperkalemia","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glycerylphosphate","slug":"calcium-glycerylphosphate","company":""},{"name":"patiromer calcium","slug":"patiromer-calcium","company":"Relypsa Inc"}],"globalPrevalence":null},{"indication":"Hypermagnesemia","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium glycerylphosphate","slug":"calcium-glycerylphosphate","company":""}],"globalPrevalence":null},{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Hypocalcemic tetany","otherDrugs":[{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium chloride","slug":"calcium-chloride","company":"Baxter Hlthcare"},{"name":"calcium gluconate","slug":"calcium-gluconate","company":""},{"name":"calcium glycerylphosphate","slug":"calcium-glycerylphosphate","company":""}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"calcium glucoheptonate","explanation":"","oneSentence":"","technicalDetail":"Calcium Gluceptate works by providing a calcium glucoheptonate complex, which dissociates in the bloodstream to release calcium ions (Ca2+). These ions then bind to various proteins and enzymes, helping to restore normal calcium homeostasis and alleviate symptoms associated with hypocalcemia."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Calcium_glucoheptonate","title":"Calcium glucoheptonate","extract":"Calcium glucoheptonate is a highly water soluble mineral supplement."},"commercial":{"launchDate":"1972","_launchSource":"DrugCentral (FDA 1972-12-04, ABBOTT)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4433","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=calcium%20glucoheptonate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium glucoheptonate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Calcium_glucoheptonate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:09:04.036984","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:50:15.089510+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"calcium phosphate","drugSlug":"calcium-phosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium gluconate","drugSlug":"calcium-gluconate","fdaApproval":"","patentExpiry":"Jul 25, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"calcium carbonate","drugSlug":"calcium-carbonate","fdaApproval":"2000-10-16","relationship":"same-class"},{"drugName":"calcium chloride","drugSlug":"calcium-chloride","fdaApproval":"1971-03-22","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"calcium glycerylphosphate","drugSlug":"calcium-glycerylphosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium citrate","drugSlug":"calcium-citrate","fdaApproval":"","relationship":"same-class"}],"genericName":"calcium glucoheptonate","indications":{"approved":[{"name":"Cardiac arrest","source":"DrugCentral","snomedId":410429000,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Disorder of electrolytes","source":"DrugCentral","snomedId":237840007,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Hyperkalemia","source":"DrugCentral","snomedId":14140009,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Hypermagnesemia","source":"DrugCentral","snomedId":66978005,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Hypocalcemia","source":"DrugCentral","snomedId":5291005,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Hypocalcemic tetany","source":"DrugCentral","snomedId":190869004,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"}],"offLabel":[{"name":"Neonatal hypocalcemic tetany","source":"DrugCentral","drugName":"calcium glucoheptonate","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"calcium-phosphate","brandName":"calcium phosphate","genericName":"calcium phosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-gluconate","brandName":"calcium gluconate","genericName":"calcium gluconate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-carbonate","brandName":"calcium carbonate","genericName":"calcium carbonate","approvalYear":"2000","relationship":"same-class"},{"drugId":"calcium-chloride","brandName":"calcium chloride","genericName":"calcium chloride","approvalYear":"1971","relationship":"same-class"},{"drugId":"calcium-glycerylphosphate","brandName":"calcium glycerylphosphate","genericName":"calcium glycerylphosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-citrate","brandName":"calcium citrate","genericName":"calcium citrate","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07173855","phase":"PHASE4","title":"Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients","status":"RECRUITING","sponsor":"Scarborough General Hospital","startDate":"2025-11-25","conditions":["Critical Illness"],"enrollment":3253,"completionDate":"2027-06-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Intravenous","formulation":"Injection","formulations":[{"form":"INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION","route":"INTRAVENOUS","productName":"Glucoheptonate"}]},"crossReferences":{"NUI":"N0000145877","MMSL":"18","NDDF":"000776","UNII":"L11651398J","VUID":"4017490","CHEBI":"CHEBI:3314","VANDF":"4017490","INN_ID":"709","RXNORM":"47618","UMLSCUI":"C0108111","chemblId":"CHEMBL4303148","ChEMBL_ID":"CHEMBL1237066","KEGG_DRUG":"D00934","DRUGBANK_ID":"DB00326","PUBCHEM_CID":"62859","MESH_SUPPLEMENTAL_RECORD_UI":"C007852"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[{"period":"1972-","companyName":"Abbott","relationship":"Original Developer"}],"publicationCount":7,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"A12AA10","allCodes":["A12AA10"]},"biosimilarFilings":[],"originalDeveloper":"Abbott","recentPublications":[{"date":"2020 Apr","pmid":"32302064","title":"Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium carbonate.","journal":"Pharmacology research & perspectives"},{"date":"2019","pmid":"31498830","title":"Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro.","journal":"PloS one"},{"date":"2018 Oct","pmid":"30100514","title":"Short communication: The effect of calcium supplementation at calving on neutrophil function.","journal":"Journal of dairy science"},{"date":"1999 Oct","pmid":"10576416","title":"Effects of estradiol and calcium on gonadotrophic cells in middle-aged female rats.","journal":"The Histochemical journal"},{"date":"1998 Apr","pmid":"9587629","title":"Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium.","journal":"Acta histochemica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Abbott","companyId":"abbott","modality":"Small Molecule","firstApprovalDate":"1972","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:50:15.089510+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}