{"id":"calcium-citrate-with-vitamin-d2","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Kidney stone formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcium citrate is a soluble calcium salt that does not require gastric acid for absorption, making it suitable for patients with achlorhydria or those taking acid-suppressing medications. Vitamin D2 (ergocalciferol) acts as a hormone precursor, undergoing hepatic and renal hydroxylation to form the active metabolite calcitriol, which increases intestinal calcium and phosphate absorption and promotes bone mineralization. Together, these agents address calcium and vitamin D deficiency.","oneSentence":"Calcium citrate provides bioavailable calcium for bone mineralization and metabolic function, while vitamin D2 enhances intestinal calcium absorption and regulates calcium-phosphate homeostasis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:36.950Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Calcium and vitamin D deficiency"},{"name":"Osteoporosis prevention and treatment"},{"name":"Hypoparathyroidism"}]},"trialDetails":[{"nctId":"NCT03621553","phase":"PHASE4","title":"Vitamin D Homeostasis in Sarcoidosis","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2010-07-01","conditions":"Sarcoidosis, Vitamin D Insufficiency","enrollment":90}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"APPETITE DISORDER"},{"count":1,"reaction":"ASTHENIA"},{"count":1,"reaction":"CONSTIPATION"},{"count":1,"reaction":"DIARRHOEA"},{"count":1,"reaction":"DYSGEUSIA"},{"count":1,"reaction":"FATIGUE"},{"count":1,"reaction":"MUSCLE SPASMS"},{"count":1,"reaction":"NAUSEA"},{"count":1,"reaction":"NEUROPATHY PERIPHERAL"},{"count":1,"reaction":"PLASMA CELL MYELOMA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Citracal"],"phase":"marketed","status":"active","brandName":"Calcium Citrate with Vitamin D2","genericName":"Calcium Citrate with Vitamin D2","companyName":"University of Texas Southwestern Medical Center","companyId":"university-of-texas-southwestern-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium citrate provides bioavailable calcium for bone mineralization and metabolic function, while vitamin D2 enhances intestinal calcium absorption and regulates calcium-phosphate homeostasis. Used for Calcium and vitamin D deficiency, Osteoporosis prevention and treatment, Hypoparathyroidism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}