{"id":"calcium-citrate","rwe":[{"pmid":"41806228","year":"2026","title":"Effect of Calcium Citrate Versus Calcium Carbonate on Parathyroid Hormone Levels in Patients Undergoing Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","finding":"","journal":"Obesity surgery","studyType":"Clinical Study"},{"pmid":"41775114","year":"2026","title":"Translational framework combining machine learning and in vivo screening for aminoglycoside ototoxicity prevention.","finding":"","journal":"Hearing research","studyType":"Clinical Study"},{"pmid":"41746376","year":"2026","title":"Pure vs. mixed calcium oxalate nephrolithiasis: metabolic determinants and stratified management strategies.","finding":"","journal":"World journal of urology","studyType":"Clinical Study"},{"pmid":"41717430","year":"2026","title":"Evaluation of drug-excipient compatibility of ibuprofen with eggshell-derived calcium citrate using FTIR, DSC, and molecular docking studies.","finding":"","journal":"In silico pharmacology","studyType":"Clinical Study"},{"pmid":"41673302","year":"2026","title":"Urinary calcium-to-citrate ratio predicts kidney stone risk in children under the age of two years.","finding":"","journal":"Pediatric nephrology (Berlin, Germany)","studyType":"Clinical Study"}],"_fda":{"id":"47e8233b-c64c-b42d-e063-6294a90a14e3","set_id":"06c529fc-272c-f889-f5e5-7f3e5ef2c59d","openfda":{"upc":["0301780891308"],"rxcui":["1535150"],"spl_id":["47e8233b-c64c-b42d-e063-6294a90a14e3"],"brand_name":["CitraNatal Assure"],"spl_set_id":["06c529fc-272c-f889-f5e5-7f3e5ef2c59d"],"package_ndc":["0178-0891-30"],"product_ndc":["0178-0891"],"generic_name":["ASCORBIC ACID, CALCIUM CITRATE, IRON, VITAMIN D, DL- ALPHA- TOCOPHEROL ACETATE, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE HYDROCHLORIDE, FOLIC ACID, IODINE, ZINC, COPPER, DOCUSATE SODIUM, DOCONEXENT AND ICOSAPENT"],"product_type":["HUMAN PRESCRIPTION DRUG"],"manufacturer_name":["Mission Pharmacal Company"],"is_original_packager":[true]},"version":"12","warnings":["WARNING Ingestion of more than 3 grams of omega-3 fatty acids per day has been shown to have potential antithrombotic effects, including an increased bleeding time and INR. Administration of omega-3 fatty acids should be avoided in patients on anticoagulants and in those known to have an inherited or acquired bleeding diathesis.","WARNING Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B 12 is deficient."],"description":["DESCRIPTION CitraNatal Assure ® is a prescription prenatal/postnatal multivitamin/mineral tablet with Ferr-Ease ® , a patented dual-iron delivery comprising both a quick release and slow release iron, and a capsule of an essential fatty acid. The prenatal vitamin is a white, coated, oval multivitamin/mineral tablet. The tablet is debossed \"0891\" on one side and is blank on the other. The essential fatty acid DHA capsule is caramel colored and contains a light yellow to orange semi-solid mixture. Each prenatal capsule contains: Vitamin C (Ascorbic acid) 120 mg Calcium (Calcium citrate) 124 mg Iron (Carbonyl iron, ferrous gluconate) 35 mg Vitamin D 3 (Cholecalciferol) 400 IU Vitamin E (dl-alpha tocopheryl acetate) 30 IU Thiamin (Vitamin B 1 ) 3 mg Riboflavin (Vitamin B 2 ) 3.4 mg Niacinamide (Vitamin B 3 ) 20 mg Vitamin B 6 (Pyridoxine HCl) 25 mg Folic Acid 1 mg Iodine (Potassium iodide) 150 mcg Zinc (Zinc oxide) 25 mg Copper (Cupric oxide) 2 mg Docusate Sodium 50 mg Each DHA gelatin capsule contains: Docosahexaenoic Acid (DHA, 40% from 750 mg Algal Oil) 300 mg Eicosapentaenoic Acid (EPA) Not more than 0.750 mg Other ingredients in DHA gelatin capsule: Gelatin, sunflower oil, glycerin, caramel color, sunflower lecithin, rosemary extract, tocopherols, ascorbyl palmitate."],"precautions":["PRECAUTIONS Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress."],"how_supplied":["Six child-resistant blister packs of 5 tablets and 5 capsules each - NDC 0178-0891-30"],"boxed_warning":["WARNING Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately."],"effective_time":"20260108","adverse_reactions":["ADVERSE REACTIONS Allergic sensitization has been reported following both oral and parenteral administration of folic acid."],"contraindications":["CONTRAINDICATIONS This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."],"description_table":["<table ID=\"t251281397055650\" width=\"80%\"><col align=\"left\" valign=\"top\" width=\"60%\"/><col align=\"right\" valign=\"top\" width=\"30%\"/><col align=\"left\" valign=\"top\" width=\"10%\"/><tbody><tr styleCode=\"Toprule\"><td colspan=\"3\"><content styleCode=\"bold\">Each prenatal capsule contains:</content></td></tr><tr><td>Vitamin C (Ascorbic acid)</td><td>120 </td><td>mg</td></tr><tr><td>Calcium (Calcium citrate)</td><td>124</td><td>mg</td></tr><tr><td>Iron (Carbonyl iron, ferrous gluconate)</td><td>35 </td><td>mg</td></tr><tr><td>Vitamin D <sub>3</sub>(Cholecalciferol) </td><td>400 </td><td>IU</td></tr><tr><td>Vitamin E (dl-alpha tocopheryl acetate)</td><td>30 </td><td>IU</td></tr><tr><td>Thiamin (Vitamin B <sub>1</sub>) </td><td>3 </td><td>mg</td></tr><tr><td>Riboflavin (Vitamin B <sub>2</sub>) </td><td>3.4 </td><td>mg</td></tr><tr><td>Niacinamide (Vitamin B <sub>3</sub>) </td><td>20 </td><td>mg</td></tr><tr><td>Vitamin B <sub>6</sub>(Pyridoxine HCl) </td><td>25 </td><td>mg</td></tr><tr><td>Folic Acid</td><td>1 </td><td>mg</td></tr><tr><td>Iodine (Potassium iodide)</td><td>150 </td><td>mcg</td></tr><tr><td>Zinc (Zinc oxide)</td><td>25 </td><td>mg</td></tr><tr><td>Copper (Cupric oxide)</td><td>2 </td><td>mg</td></tr><tr><td>Docusate Sodium</td><td>50 </td><td>mg</td></tr><tr><td colspan=\"3\"><content styleCode=\"bold\">Each DHA gelatin capsule contains:</content></td></tr><tr><td>Docosahexaenoic Acid (DHA, 40% from 750 mg Algal Oil)</td><td>300 </td><td>mg</td></tr><tr styleCode=\"Botrule\"><td>Eicosapentaenoic Acid (EPA)</td><td>Not more than 0.750 </td><td>mg</td></tr></tbody></table>"],"storage_and_handling":["STORAGE Store at 20–25°C (68–77°F) NOTICE Contact with moisture can discolor or erode the tablet."],"indications_and_usage":["INDICATIONS CitraNatal Assure ® is a multivitamin/mineral prescription drug indicated for use in improving the nutritional status of women prior to conception, throughout pregnancy, and in the postnatal period for both lactating and nonlactating mothers."],"spl_unclassified_section":["CAUTION: Exercise caution to ensure that the prescribed dosage of DHA does not exceed 1 gram (1000 mg) per day.","To report a serious adverse event or obtain product information, call (210) 696-8400. 51062R1120 MISSION ® PHARMACAL DHA capsules manufactured for: MISSION PHARMACAL COMPANY San Antonio, TX USA 78230 1355 Prenatal tablets manufactured by: MISSION PHARMACAL COMPANY San Antonio, TX USA 78230 1355 Copyright © 2020 Mission Pharmacal Company. All rights reserved."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION One tablet and one capsule daily or as directed by a physician."],"spl_product_data_elements":["CitraNatal Assure ascorbic acid, calcium citrate, iron, vitamin d, dl- alpha- tocopherol acetate, thiamine, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, iodine, zinc, copper, docusate sodium, doconexent and icosapent Prenatal Vitamin ascorbic acid, calcium citrate, iron, vitamin d, dl- alpha- tocopherol acetate, thiamine, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, iodine, zinc, copper and docusate sodium POVIDONE K30 CROSCARMELLOSE SODIUM TITANIUM DIOXIDE MAGNESIUM SILICATE MAGNESIUM STEARATE SHELLAC VANILLIN ASCORBIC ACID ASCORBIC ACID IRON IRON CHOLECALCIFEROL CHOLECALCIFEROL ALPHA-TOCOPHEROL ALPHA-TOCOPHEROL RIBOFLAVIN RIBOFLAVIN NIACINAMIDE NIACINAMIDE PYRIDOXINE HYDROCHLORIDE PYRIDOXINE FOLIC ACID FOLIC ACID IODINE IODINE ZINC ZINC COPPER COPPER DOCUSATE SODIUM DOCUSATE THIAMINE THIAMINE ION CALCIUM CITRATE CALCIUM CATION CALCIUM CITRATE ANHYDROUS 0891 DHA doconexent and icosapent GELATIN SUNFLOWER OIL GLYCERIN LECITHIN, SUNFLOWER ROSEMARY TOCOPHEROL ASCORBYL PALMITATE DOCONEXENT DOCONEXENT ICOSAPENT ICOSAPENT caramel color"],"package_label_principal_display_panel":["CitraNatal Assure Retail Blister Pack NDC 0178–0891–30 Retail Blister","Retail Carton Label"]},"tags":[{"label":"calcium citrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12AA13","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Liquid","category":"form"},{"label":"Tablet","category":"form"},{"label":"Active","category":"status"},{"label":"Hypocalcemia","category":"indication"},{"label":"Osteoporosis","category":"indication"},{"label":"Postmenopausal osteoporosis","category":"indication"},{"label":"Food Additives","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":["WARNING Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately."],"safetySignals":[{"date":"","signal":"MATERNAL EXPOSURE DURING PREGNANCY","source":"FDA FAERS","actionTaken":"4 reports"},{"date":"","signal":"ARTHRALGIA","source":"FDA FAERS","actionTaken":"3 reports"},{"date":"","signal":"FALL","source":"FDA FAERS","actionTaken":"3 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"3 reports"},{"date":"","signal":"PRURITUS","source":"FDA FAERS","actionTaken":"3 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"2 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"2 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"2 reports"},{"date":"","signal":"HYPOAESTHESIA","source":"FDA FAERS","actionTaken":"2 reports"},{"date":"","signal":"INJECTION SITE PAIN","source":"FDA FAERS","actionTaken":"2 reports"}],"commonSideEffects":[{"effect":"Allergic sensitization","drugRate":"","severity":"serious","_validated":false,"_confidence":0.3}],"contraindications":["This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CALCIUM CITRATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:01:36.647641+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:02:08.807400+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:01:42.130617+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CALCIUM CITRATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:01:42.478837+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:02:02.699757+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (boxed_warning)","rawText":"WARNING Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:01:34.039158+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:01:45.302769+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2106123/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:01:43.517801+00:00"},"safety.commonSideEffects":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"ADVERSE REACTIONS Allergic sensitization has been reported following both oral and parenteral administration of folic acid.","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:01:48.901705+00:00"},"safety.contraindications":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:01:52.108832+00:00"}},"allNames":["calcium citrate"],"offLabel":[],"synonyms":["calcium citrate"],"timeline":[],"aiSummary":"Calcium citrate is a marketed supplement primarily indicated for preconception nutritional support, competing in a crowded market of calcium-based products. Its key strength lies in its mechanism of providing essential calcium ions for bone health and density, supported by a key composition patent expiring in 2028. The primary risk is the presence of multiple same-class competitors, including off-patent calcium chloride and patent-protected calcium gluconate, which may limit market share and revenue growth.","ecosystem":[{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Osteoporosis","otherDrugs":[{"name":"abaloparatide","slug":"abaloparatide","company":"Radius Health Inc"},{"name":"calcium gluconate","slug":"calcium-gluconate","company":""},{"name":"calcium phosphate","slug":"calcium-phosphate","company":""},{"name":"colecalciferol","slug":"colecalciferol","company":"Sandoz"}],"globalPrevalence":200000000},{"indication":"Postmenopausal osteoporosis","otherDrugs":[{"name":"alendronic acid","slug":"alendronic-acid","company":"Merck And Co Inc"},{"name":"bazedoxifene","slug":"bazedoxifene","company":"Wyeth Pharms Pfizer"},{"name":"calcitonin (salmon synthetic)","slug":"calcitonin-(salmon-synthetic)","company":"Sanofi Aventis Us"},{"name":"calcium phosphate","slug":"calcium-phosphate","company":""}],"globalPrevalence":200000000}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"calcium citrate","explanation":"","oneSentence":"","technicalDetail":"Calcium citrate acts as a calcium supplement by increasing the bioavailability of calcium ions in the gastrointestinal tract, which are then absorbed into the bloodstream and utilized by the body for bone mineralization and density."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4479","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CALCIUM%20CITRATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CALCIUM CITRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:08:46.963747","_validation":{"fieldsValidated":3,"lastValidatedAt":"2026-04-20T00:02:08.808613+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"calcium phosphate","drugSlug":"calcium-phosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium gluconate","drugSlug":"calcium-gluconate","fdaApproval":"","patentExpiry":"Jul 25, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"calcium carbonate","drugSlug":"calcium-carbonate","fdaApproval":"2000-10-16","relationship":"same-class"},{"drugName":"calcium chloride","drugSlug":"calcium-chloride","fdaApproval":"1971-03-22","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"calcium glycerylphosphate","drugSlug":"calcium-glycerylphosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"calcium glucoheptonate","drugSlug":"calcium-glucoheptonate","fdaApproval":"1972-12-04","relationship":"same-class"}],"genericName":"calcium citrate","indications":{"approved":[{"id":"calcium-citrate-preconception-nutritional-supp","name":"Preconception Nutritional Support","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Women planning to conceive","pivotalTrial":null,"restrictions":[],"patientPopulation":"Women planning to conceive","diagnosticRequired":null,"brandNameForIndication":""},{"id":"calcium-citrate-pregnancy-nutritional-support","name":"Pregnancy Nutritional Support","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Pregnant women","pivotalTrial":null,"restrictions":[],"patientPopulation":"Pregnant women","diagnosticRequired":null,"brandNameForIndication":""},{"id":"calcium-citrate-postnatal-nutritional-support","name":"Postnatal Nutritional Support","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Postnatal women (lactating and nonlactating)","pivotalTrial":null,"restrictions":[],"patientPopulation":"Postnatal women (lactating and nonlactating)","diagnosticRequired":null,"brandNameForIndication":""}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"calcium-phosphate","brandName":"calcium phosphate","genericName":"calcium phosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-gluconate","brandName":"calcium gluconate","genericName":"calcium gluconate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-carbonate","brandName":"calcium carbonate","genericName":"calcium carbonate","approvalYear":"2000","relationship":"same-class"},{"drugId":"calcium-chloride","brandName":"calcium chloride","genericName":"calcium chloride","approvalYear":"1971","relationship":"same-class"},{"drugId":"calcium-glycerylphosphate","brandName":"calcium glycerylphosphate","genericName":"calcium glycerylphosphate","approvalYear":"","relationship":"same-class"},{"drugId":"calcium-glucoheptonate","brandName":"calcium glucoheptonate","genericName":"calcium glucoheptonate","approvalYear":"1972","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04847453","phase":"PHASE1","title":"Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2022-08-03","conditions":["Recurrent AL Amyloidosis","Refractory AL Amyloidosis"],"enrollment":24,"completionDate":"2026-06-30"},{"nctId":"NCT07444710","phase":"PHASE1","title":"Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma","status":"NOT_YET_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2026-08-20","conditions":["Ann Arbor Stage II Mantle Cell Lymphoma","Ann Arbor Stage III Mantle Cell Lymphoma","Ann Arbor Stage IV Mantle Cell Lymphoma"],"enrollment":16,"completionDate":"2027-09-01"},{"nctId":"NCT04930237","phase":"","title":"RELISTOR's Effects on Opioid-Induced Constipation","status":"WITHDRAWN","sponsor":"Methodist Health System","startDate":"2021-07-01","conditions":["OIC"],"enrollment":0,"completionDate":"2022-04-22"},{"nctId":"NCT03418038","phase":"PHASE2","title":"Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic 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Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2007-10-22","conditions":["Anaplastic Medulloblastoma","Medulloblastoma","Supratentorial Embryonal Tumor, Not Otherwise Specified","Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor"],"enrollment":91,"completionDate":"2025-09-30"},{"nctId":"NCT04481789","phase":"PHASE1","title":"Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study)","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2018-10-17","conditions":["Healthy Adult Subjects"],"enrollment":84,"completionDate":"2019-01-08"},{"nctId":"NCT03621553","phase":"PHASE4","title":"Vitamin D Homeostasis in Sarcoidosis","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2010-07-01","conditions":["Sarcoidosis","Vitamin D Insufficiency"],"enrollment":90,"completionDate":"2026-12-30"},{"nctId":"NCT07306611","phase":"PHASE1,PHASE2","title":"Regenerative Treatment of Female Genital Atrophy","status":"COMPLETED","sponsor":"AndreiaAntunes","startDate":"2024-06-04","conditions":["Vulvo Vaginal Atrophy"],"enrollment":30,"completionDate":"2025-11-26"},{"nctId":"NCT02352181","phase":"NA","title":"Management of Coagulopathy During Orthotopic Liver Transplantation. Comparison Between ROTEM-based Management and Standard Biological Assessment.","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2014-12","conditions":["Liver Transplantation"],"enrollment":82,"completionDate":"2016-11"},{"nctId":"NCT05399537","phase":"PHASE3","title":"Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT","status":"RECRUITING","sponsor":"Vantive Health LLC","startDate":"2024-07-12","conditions":["Regional Citrate Anticoagulation (RCA)","Continuous Renal Replacement Therapy (CRRT)","Acute Kidney Injury (AKI)"],"enrollment":40,"completionDate":"2026-12"},{"nctId":"NCT03842657","phase":"PHASE2","title":"Regional Anticoagulation of Dialysis Circuits With a Calcium-free Citrate-containing Dialysate","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2019-07-05","conditions":["Hemodialysis Complication","Bleeding"],"enrollment":97,"completionDate":"2021-09-13"},{"nctId":"NCT07255820","phase":"PHASE4","title":"Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol","status":"NOT_YET_RECRUITING","sponsor":"Bahria University","startDate":"2026-01-01","conditions":["Type 2 Diabetes Mellitus","Hypercholesterolemia / Elevated LDL Cholesterol"],"enrollment":126,"completionDate":"2026-06-30"},{"nctId":"NCT06742853","phase":"PHASE1","title":"A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2024-12-20","conditions":["Dyslipidemia"],"enrollment":81,"completionDate":"2025-10-29"},{"nctId":"NCT05365477","phase":"PHASE4","title":"Empiric Versus Selective Prevention Strategies for Kidney Stone Disease","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2022-08-04","conditions":["Kidney 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