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If pregnant or breast-feeding, ask a health professional before use."],"questions":["Questions or Comments Call 631-981-4600, Monday-Friday, 8.30 am – 4.30 pm ET TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING Manufactured by: Advance Pharmaceutical Inc. Holtsville, NY 11742"],"effective_time":"20171222","active_ingredient":["Active Ingredient (in each tablet) Calcium Carbonate 10 gr (648 mg)"],"inactive_ingredient":["Inactive Ingredients Croscarmellose sodium, magnesium stearate, maltodextrin, microcrystalline cellulose, stearic acid"],"indications_and_usage":["Uses relieves acid indigestion heartburn sour stomach upset stomach associated with these symptoms"],"spl_unclassified_section":["Other Information each tablet contains: calcium 260 mg store at room temperature 15-30 °C (59-86 °F) For 1000 Count: This is a bulk package. Dispense contents in a tight, light-resistant container with a child-resistant closure as defined in the USP."],"dosage_and_administration":["Directions take one to four tablets daily. do not take more than 4 tablets in 24 hours do not use the maximum dosage for more than 2 weeks"],"spl_product_data_elements":["ANTACID Calcium Carbonate CROSCARMELLOSE SODIUM MAGNESIUM STEARATE MALTODEXTRIN CELLULOSE, MICROCRYSTALLINE STEARIC ACID CALCIUM CARBONATE CALCIUM CATION CARBONATE ION off AP;025"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["PACKAGE LABEL.PRINCIPAL DISPLAY PANEL Calcium Carbonate 10 gr Antacid tablets NDC: 17714-025-01 – 100 COUNT NDC: 17714-025-10 – 1000 COUNT (THIS PACKAGE FOR HOUSEHOLDS WITHOUT YOUNG CHILDREN) 17ad8654-figure-01 17ad8654-figure-02"]},"tags":[],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"6595 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"6127 reports"},{"date":"","signal":"CHRONIC KIDNEY DISEASE","source":"FDA FAERS","actionTaken":"5681 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"5469 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"5218 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"5216 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"5083 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"4895 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"4688 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"4518 reports"}],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"approved","trials":["NCT03468959","NCT00682214","NCT02361372","NCT05619315","NCT05443360","NCT06210750","NCT01266850","NCT01739855","NCT04586348","NCT02195895","NCT05963022","NCT06523881","NCT04764565","NCT03891095","NCT01676636","NCT04308473","NCT04914936","NCT02969850","NCT05612984","NCT02281721","NCT01578200","NCT04299633","NCT02561169","NCT03113994","NCT01052051","NCT03612466","NCT01950169","NCT01803607","NCT03425747","NCT06026540","NCT00145704","NCT03861039","NCT01005381","NCT01179503","NCT06568315","NCT05920915","NCT01589991","NCT01595282","NCT02143505","NCT06252337","NCT03890718","NCT06789523","NCT05370898","NCT02457247","NCT02602704","NCT01047098","NCT05100836","NCT03547661","NCT05666583","NCT06673485"],"aliases":["Tums","Caltrate","Os-Cal"],"patents":[],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-08-21","unitCost":"$0.0083/EA","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$3","description":"CALCIUM CARBONATE 648 MG TAB","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=calcium carbonate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:03:15.369515+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:03:22.923292+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:03:13.424317+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium carbonate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:03:23.688160+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:03:11.201695+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:03:11.201971+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:03:33.234099+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200539/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:03:24.607229+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"part331","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:03:11.202000+00:00"}},"allNames":"tums","offLabel":[],"timeline":[],"aiSummary":"Tums is a small molecule medication that contains calcium carbonate, a common substance found in rocks and used in agriculture. 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