{"id":"calcium-acetate-and-magnesium-carbonate","rwe":[{"pmid":"30132304","year":"2018","title":"Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"29479762","year":"2019","title":"Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.","finding":"","journal":"Nephrology (Carlton, Vic.)","studyType":"Clinical Study"},{"pmid":"28464802","year":"2017","title":"Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.","finding":"","journal":"BMC nephrology","studyType":"Clinical Study"},{"pmid":"27900961","year":"2016","title":"Efficacy and safety of calcium acetate-magnesium carbonate in the treatment of hyperphosphatemia in dialysis patients.","finding":"","journal":"Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia","studyType":"Clinical Study"},{"pmid":"27023929","year":"2016","title":"Calcium Acetate/Magnesium Carbonate and Cardiovascular Risk Factors in Chronic Hemodialysis Patients.","finding":"","journal":"Nephron","studyType":"Clinical Study"}],"tags":[{"label":"calcium acetate and magnesium carbonate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V03AE04","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["calcium acetate and magnesium carbonate"],"offLabel":[],"synonyms":["calcium acetate and magnesium carbonate"],"timeline":[],"aiSummary":"Calcium acetate and magnesium carbonate are small molecule compounds used to treat hyperphosphatemia in patients with chronic kidney disease. They work by binding to excess phosphate in the gastrointestinal tract, reducing its absorption into the bloodstream. The exact mechanism of action is not fully understood, but it is believed to involve the formation of insoluble complexes with phosphate ions. The commercial status of calcium acetate and magnesium carbonate is not specified, but they are likely available as branded or generic products. Key safety considerations include potential gastrointestinal side effects and interactions with other medications.","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"calcium acetate and magnesium carbonate","explanation":"Imagine your body is like a sponge that soaks up nutrients from the food you eat. Calcium acetate and magnesium carbonate work by forming a kind of 'sponge' in your gut that traps excess phosphate, preventing it from being absorbed into your bloodstream. This helps to keep your phosphate levels under control.","oneSentence":"Calcium acetate and magnesium carbonate bind to excess phosphate in the gastrointestinal tract, reducing its absorption into the bloodstream.","technicalDetail":"Calcium acetate and magnesium carbonate exert their effects through the formation of insoluble complexes with phosphate ions, which are then excreted in the feces, thereby reducing phosphate absorption in the gastrointestinal tract."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4430","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=calcium%20acetate%20and%20magnesium%20carbonate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=calcium acetate and magnesium carbonate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:06:47.144495","biosimilars":[],"competitors":[{"drugName":"sodium polystyrene sulfonate","drugSlug":"sodium-polystyrene-sulfonate","fdaApproval":"1958-06-05","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sevelamer","drugSlug":"sevelamer","fdaApproval":"1998-10-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lanthanum carbonate","drugSlug":"lanthanum-carbonate","fdaApproval":"2004-10-26","patentExpiry":"Dec 1, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sucroferric oxyhydroxide","drugSlug":"sucroferric-oxyhydroxide","fdaApproval":"2013-11-27","relationship":"same-class"},{"drugName":"calcium acetate","drugSlug":"calcium-acetate","fdaApproval":"1982-05-06","patentExpiry":"Jul 20, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ferric citrate","drugSlug":"ferric-citrate","fdaApproval":"2014-09-05","patentExpiry":"Jul 21, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"patiromer calcium","drugSlug":"patiromer-calcium","fdaApproval":"2015-10-21","relationship":"same-class"},{"drugName":"sodium zirconium cyclosilicate","drugSlug":"sodium-zirconium-cyclosilicate","fdaApproval":"2018-05-18","patentExpiry":"Oct 22, 2033","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"calcium acetate and magnesium carbonate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sodium-polystyrene-sulfonate","brandName":"sodium polystyrene sulfonate","genericName":"sodium polystyrene sulfonate","approvalYear":"1958","relationship":"same-class"},{"drugId":"sevelamer","brandName":"sevelamer","genericName":"sevelamer","approvalYear":"1998","relationship":"same-class"},{"drugId":"lanthanum-carbonate","brandName":"lanthanum carbonate","genericName":"lanthanum carbonate","approvalYear":"2004","relationship":"same-class"},{"drugId":"sucroferric-oxyhydroxide","brandName":"sucroferric oxyhydroxide","genericName":"sucroferric oxyhydroxide","approvalYear":"2013","relationship":"same-class"},{"drugId":"calcium-acetate","brandName":"calcium acetate","genericName":"calcium acetate","approvalYear":"1982","relationship":"same-class"},{"drugId":"ferric-citrate","brandName":"ferric citrate","genericName":"ferric citrate","approvalYear":"2014","relationship":"same-class"},{"drugId":"patiromer-calcium","brandName":"patiromer calcium","genericName":"patiromer calcium","approvalYear":"2015","relationship":"same-class"},{"drugId":"sodium-zirconium-cyclosilicate","brandName":"sodium zirconium cyclosilicate","genericName":"sodium zirconium cyclosilicate","approvalYear":"2018","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04586348","phase":"PHASE4","title":"Prenatal Iodine Supplementation and Early Childhood Neurodevelopment","status":"ACTIVE_NOT_RECRUITING","sponsor":"South Australian Health and Medical Research Institute","startDate":"2021-01-18","conditions":["Pregnancy Related","Neurodevelopmental Disorders","Nutrition Disorder, Fetal"],"enrollment":794,"completionDate":"2025-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"d04304","RXNORM":"214344","UMLSCUI":"C0717539"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"V03AE04","allCodes":["V03AE04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2018 Aug 22","pmid":"30132304","title":"Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).","journal":"The Cochrane database of systematic reviews"},{"date":"2019 Feb","pmid":"29479762","title":"Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.","journal":"Nephrology (Carlton, Vic.)"},{"date":"2017 May 2","pmid":"28464802","title":"Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.","journal":"BMC nephrology"},{"date":"2016 Nov-Dec","pmid":"27900961","title":"Efficacy and safety of calcium acetate-magnesium carbonate in the treatment of hyperphosphatemia in dialysis patients.","journal":"Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia"},{"date":"2016","pmid":"27023929","title":"Calcium Acetate/Magnesium Carbonate and Cardiovascular Risk Factors in Chronic Hemodialysis Patients.","journal":"Nephron"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"calcium acetate and magnesium carbonate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}