{"id":"calcitriol-rocaltrol","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hyperphosphatemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Weakness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcitriol (1,25-dihydroxyvitamin D3) is the hormonally active metabolite of vitamin D that acts as a ligand for the vitamin D receptor (VDR), a nuclear receptor that regulates gene transcription. It increases intestinal absorption of calcium and phosphate, promotes bone mineralization, and modulates parathyroid hormone secretion to maintain serum calcium and phosphate levels within normal ranges.","oneSentence":"Calcitriol is the active form of vitamin D that binds to vitamin D receptors to regulate calcium and phosphate homeostasis and promote bone mineralization.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:16.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypocalcemia in patients with chronic kidney disease"},{"name":"Hypoparathyroidism"},{"name":"Vitamin D-dependent rickets"},{"name":"Hypophosphatemia"}]},"trialDetails":[{"nctId":"NCT02859896","phase":"PHASE3","title":"Safety and Efficacy of Hectorol in Pediatric Patients With Chronic Kidney Disease Stage 3 and 4 With Secondary Hyperparathyroidism Not Yet on Dialysis","status":"TERMINATED","sponsor":"Sanofi","startDate":"2017-01-19","conditions":"Secondary Hyperparathyroidism-Chronic Kidney Disease","enrollment":21},{"nctId":"NCT06464718","phase":"NA","title":"Effectiveness of Calcium and Vitamin D, With and Without Collagen Peptide, in Enhancing Bone Mineral Density on Postmenopausal Women With Osteopenia","status":"COMPLETED","sponsor":"Frontier Medical and Dental College, Abbotabad","startDate":"2022-06-20","conditions":"Osteopenia","enrollment":30},{"nctId":"NCT01725113","phase":"PHASE4","title":"Management of Mineral and Bone Disease in Hemodialysis-Calcitriol vs. Paricalcitol","status":"TERMINATED","sponsor":"Winthrop University Hospital","startDate":"2012-11","conditions":"Kidney Failure, Secondary Hyperparathyroidism, Hyperphosphatemia","enrollment":16},{"nctId":"NCT00658788","phase":"PHASE3","title":"Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-03","conditions":"Psoriasis","enrollment":305},{"nctId":"NCT00988637","phase":"PHASE4","title":"Evaluate Safety/Efficacy of Two Treatment Regimens for Vectical™ Ointment & Clobex® Spray for Moderate Plaque Psoriasis","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-10","conditions":"Plaque Psoriasis","enrollment":138},{"nctId":"NCT00925704","phase":"PHASE1","title":"The Pharmacokinetics of Rocaltrol When Administered Alone or in Combination With Fosrenol or Renvela in Healthy Volunteers","status":"COMPLETED","sponsor":"Shire","startDate":"2009-06-01","conditions":"Healthy","enrollment":41},{"nctId":"NCT03261336","phase":"PHASE2","title":"Oral Calcitriol With Ketoconazole in CRPC","status":"TERMINATED","sponsor":"Donald Trump, MD","startDate":"2017-01-06","conditions":"Castration-resistant Prostate Cancer","enrollment":1},{"nctId":"NCT04637360","phase":"NA","title":"Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment","status":"COMPLETED","sponsor":"Min-Sheng General Hospital","startDate":"2018-01-01","conditions":"Hyperparathyroidism; Secondary, Renal","enrollment":40},{"nctId":"NCT01526278","phase":"PHASE1","title":"Pharmacokinetics of Maxmarvil® in Healthy Postmenopausal Women","status":"COMPLETED","sponsor":"Yuyu Pharma, Inc.","startDate":"2011-10","conditions":"Osteoporosis","enrollment":18},{"nctId":"NCT00752102","phase":"PHASE4","title":"Vitamin D and Coronary Calcification Study","status":"COMPLETED","sponsor":"Joslin Diabetes Center","startDate":"2008-09","conditions":"Chronic Kidney Disease, Vitamin D Deficiency, Coronary Calcification","enrollment":44},{"nctId":"NCT01237028","phase":"NA","title":"Additive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System Blockers","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2011-03","conditions":"IgA Nephropathy","enrollment":168},{"nctId":"NCT01012713","phase":"PHASE4","title":"Safety and Efficacy Study of Combination Treatment With Excimer Laser, Clobex Spray, and Vectical Ointment in the Treatment of Psoriasis","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2010-06","conditions":"Chronic Stable Plaque Psoriasis","enrollment":30},{"nctId":"NCT00084708","phase":"PHASE1","title":"Calcitriol and Gefitinib With or Without Dexamethasone in Treating Patients With Advanced Solid Tumors","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"2002-11","conditions":"Unspecified Adult Solid Tumor, Protocol Specific","enrollment":53},{"nctId":"NCT01512862","phase":"PHASE4","title":"Anti-proteinuric Effect of Calcitriol in Non-diabetic Kidney Disease Patients","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2012-01","conditions":"Proteinuria","enrollment":240},{"nctId":"NCT01205880","phase":"PHASE4","title":"Study to Evaluate Vectical in Combination With Clobex Spray to Treatment Plaque Psoriasis","status":"COMPLETED","sponsor":"Emer, Jason, M.D.","startDate":"2009-12","conditions":"Psoriasis","enrollment":12},{"nctId":"NCT00066885","phase":"PHASE1, PHASE2","title":"Study of DN101 and Taxotere in Patients With Advanced Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Novacea","startDate":"2003-06","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Calcijex®","Rocaltrol®"],"phase":"marketed","status":"active","brandName":"Calcitriol (Rocaltrol®)","genericName":"Calcitriol (Rocaltrol®)","companyName":"Joslin Diabetes Center","companyId":"joslin-diabetes-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcitriol is the active form of vitamin D that binds to vitamin D receptors to regulate calcium and phosphate homeostasis and promote bone mineralization. Used for Hypocalcemia in patients with chronic kidney disease, Hypoparathyroidism, Vitamin D-dependent rickets.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}