{"id":"calcipotriol-plus-hydrocortisone-ointment-vehicle","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Skin atrophy (from corticosteroid component)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriol binds to the vitamin D receptor on skin cells, normalizing their growth and maturation cycle while reducing inflammatory cytokine production. Hydrocortisone, a topical corticosteroid, suppresses local immune responses and inflammation. The combination provides synergistic efficacy for treating plaque psoriasis with reduced steroid burden compared to corticosteroid monotherapy.","oneSentence":"Calcipotriol (a vitamin D analogue) reduces keratinocyte proliferation and promotes differentiation, while hydrocortisone provides anti-inflammatory effects to treat psoriasis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:42.081Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis"}]},"trialDetails":[{"nctId":"NCT00691002","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment in Psoriasis Vulgaris on the Face and Skin Folds","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-05","conditions":"Psoriasis Vulgaris","enrollment":1245},{"nctId":"NCT00640822","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment Compared With Tacalcitol Ointment in Patients With Psoriasis on the Face and Skin Folds","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-02","conditions":"Psoriasis Vulgaris","enrollment":782},{"nctId":"NCT02973776","phase":"PHASE1","title":"Vasoconstriction Trial With LEO 90100 Aerosol Foam","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-12","conditions":"Psoriasis Vulgaris","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Calcipotriol plus hydrocortisone ointment vehicle","genericName":"Calcipotriol plus hydrocortisone ointment vehicle","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcipotriol (a vitamin D analogue) reduces keratinocyte proliferation and promotes differentiation, while hydrocortisone provides anti-inflammatory effects to treat psoriasis. Used for Plaque psoriasis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}