{"id":"calcipotriol-hydrate-daivonex","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation at application site"},{"rate":null,"effect":"Hypercalcemia (with systemic absorption)"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL4563773","moleculeType":"Unknown","molecularWeight":"412.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriol acts as a selective agonist of the vitamin D receptor (VDR), which modulates gene expression involved in cell differentiation and immune regulation in the skin. By promoting normal keratinocyte maturation and reducing abnormal proliferation, it helps normalize the pathological skin changes seen in psoriasis and other hyperproliferative skin disorders.","oneSentence":"Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell differentiation and proliferation, reducing excessive keratinocyte growth.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:59.732Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis"},{"name":"Psoriatic dermatitis"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"calcipotriol hydrate [Daivonex]","genericName":"calcipotriol hydrate [Daivonex]","companyName":"Hoffmann-La Roche","companyId":"roche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell differentiation and proliferation, reducing excessive keratinocyte growth. Used for Plaque psoriasis, Psoriatic dermatitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}